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首页> 外文期刊>Journal of genetics >Smoking modifies the effect of two independent SNPs rs5063 and rs198358 of NPPAon central obesity in the Chinese Han population
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Smoking modifies the effect of two independent SNPs rs5063 and rs198358 of NPPAon central obesity in the Chinese Han population

机译：吸烟改变了中国汉族人群中两个独立的NPPA rs5063和rs198358对中枢性肥胖的影响

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Obesity is the third most risk factors of death in the middle-income and high-income countries. Whether DNA polymorphisms in CORIN and NPPA genes were associated with obesity, and if these associations could be modified by smokingin the Chinese Han population were unknown, hence a group of 1507 participants were recruited and genotyped for 12 tag single-nucleotide polymorphisms (SNPs) of CORIN and NPPA genes. Regression models were used to test the associations of SNPs with obesity. The potential SNPa??smoking interactions were detected in regression models. NPPA SNPs rs5063 and rs198358 were associated with the body mass index (BMI) (P = 0.0053 and 0.0037, respectively). Rs198358 was associated with obesity in both univariate- and multivariable-adjusted analyses (P = 0.0138 and 0.0173, respectively). Rs5063 was associated with central obesity in both univariate- and multivariable-adjusted analyses (P = 0.0454 and 0.0361, respectively). Significant interactions between cigarette smoking and rs5063 and rs198358 were detected (P = 0.0019 and 0.0006, respectively). In subgroup analyses, rs5063 and rs198358 were associated with central obesity in smokers (P = 0.0081 and 0.0037, respectively). The results of our study demonstrated that the effect of NPPA SNPs rs5063 and rs198358 on central obesity might be modified by smoking in the Chinese Han population. Further studies are needed to confirm the associations and elucidate the underlying mechanisms.
机译：在中等收入和高收入国家，肥胖是第三大死亡风险因素。是否知道CORIN和NPPA基因中的DNA多态性是否与肥胖有关，以及是否可以通过吸烟在中国汉族人群中改变这些关联性，因此招募了1507名参与者，并对它们的12个标签单核苷酸多态性（SNP）进行了基因分型。 CORIN和NPPA基因。回归模型用于检验SNP与肥胖的关系。在回归模型中检测到了潜在的SNPa ??吸烟相互作用。 NPPA SNP rs5063和rs198358与体重指数（BMI）相关（分别为P = 0.0053和0.0037）。在单变量和多变量校正分析中，Rs198358与肥胖相关（分别为P = 0.0138和0.0173）。在单变量和多变量校正分析中，Rs5063与中枢型肥胖相关（分别为P = 0.0454和0.0361）。检测到吸烟与rs5063和rs198358之间存在显着相互作用（分别为P = 0.0019和0.0006）。在亚组分析中，rs5063和rs198358与吸烟者中枢型肥胖相关（分别为P = 0.0081和0.0037）。我们的研究结果表明，中国汉族人群吸烟可能会改变NPPA SNP rs5063和rs198358对中枢性肥胖的影响。需要进一步的研究以确认这种关联并阐明其潜在机制。

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