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首页> 外文期刊>Journal of genetics >Smoking modifies the effect of two independent SNPs rs5063 and rs198358 of NPPA on central obesity in the Chinese Han population
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Smoking modifies the effect of two independent SNPs rs5063 and rs198358 of NPPA on central obesity in the Chinese Han population

机译：吸烟改变了两个独立的SNPS RS5063和NPPA对中国汉族人口中央肥胖的影响

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摘要

Obesity is the third most risk factors of death in the middle-income and high-income countries. Whether DNA polymorphisms in CORIN and NPPA genes were associated with obesity, and if these associations could be modified by smoking in the Chinese Han population were unknown, hence a group of 1507 participants were recruited and genotyped for 12 tag single-nucleotide polymorphisms (SNPs) of CORIN and NPPA genes. Regression models were used to test the associations of SNPs with obesity. The potential SNP-smoking interactions were detected in regression models. NPPA SNPs rs5063 and rs198358 were associated with the body mass index (BMI) (P = 0.0053 and 0.0037, respectively). Rs198358 was associated with obesity in both univariate- and multivariable-adjusted analyses (P = 0.0138 and 0.0173, respectively). Rs5063 was associated with central obesity in both univariate- and multivariable-adjusted analyses (P = 0.0454 and 0.0361, respectively). Significant interactions between cigarette smoking and rs5063 and rs198358 were detected (P = 0.0019 and 0.0006, respectively). In subgroup analyses, rs5063 and rs198358 were associated with central obesity in smokers (P = 0.0081 and 0.0037, respectively). The results of our study demonstrated that the effect of NPPA SNPs rs5063 and rs198358 on central obesity might be modified by smoking in the Chinese Han population. Further studies are needed to confirm the associations and elucidate the underlying mechanisms.
机译：肥胖是中等收入和高收入国家的第三个最危险因素。是否在Corin和NPPA基因中的DNA多态性与肥胖有关，如果通过在中国汉族人群中吸烟可以修饰这些联合，因此招募了1507名参与者的组，并对12标签单核苷酸多态性进行了基因分型（SNPS）科素和NPPA基因。回归模型用于测试SNP与肥胖的关联。在回归模型中检测到潜在的SNP吸烟相互作用。 NPPA SNPS RS5063和RS198358与体重指数（BMI）相关联（P = 0.0053和0.0037）。 RS198358与单变量和多变量调整的分析（P = 0.0138和0.0173）有关的肥胖有关。 RS5063与单变量和多变量调整的分析（P = 0.0454和0.0361）中的中央肥胖有关。检测吸烟和RS5063和RS198358之间的显着相互作用（P = 0.0019和0.0006）。在亚组分析中，RS5063和RS198358与吸烟者中的中央肥胖有关（分别为0.0081和0.0037）。我们的研究结果表明，NPPA SNPS RS5063和198358对中央肥胖的影响可能会通过在中国汉族人群中吸烟来修改。需要进一步研究来确认协会并阐明潜在机制。

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  • 来源
    《Journal of genetics》 |2018年第4期|共8页
  • 作者

    Zhang Huan; Mo Xingbo; Zhou Zhengyuan; Zhu Zhengbao; Huangfu Xinfeng; Xu Tan; Wang Aili; Guo Zhirong; Zhang Yonghong;

  • 作者单位

    Soochow Univ Jiangsu Key Lab Prevent &

    Translat Med Geriatr Di Suzhou Jiangsu Peoples R China;

    Soochow Univ Jiangsu Key Lab Prevent &

    Translat Med Geriatr Di Suzhou Jiangsu Peoples R China;

    Changshu Ctr Dis Control &

    Prevent Suzhou Jiangsu Peoples R China;

    Soochow Univ Jiangsu Key Lab Prevent &

    Translat Med Geriatr Di Suzhou Jiangsu Peoples R China;

    Soochow Univ Jiangsu Key Lab Prevent &

    Translat Med Geriatr Di Suzhou Jiangsu Peoples R China;

    Soochow Univ Jiangsu Key Lab Prevent &

    Translat Med Geriatr Di Suzhou Jiangsu Peoples R China;

    Soochow Univ Jiangsu Key Lab Prevent &

    Translat Med Geriatr Di Suzhou Jiangsu Peoples R China;

    Soochow Univ Jiangsu Key Lab Prevent &

    Translat Med Geriatr Di Suzhou Jiangsu Peoples R China;

    Soochow Univ Jiangsu Key Lab Prevent &

    Translat Med Geriatr Di Suzhou Jiangsu Peoples R China;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 遗传学;
  • 关键词

    corin; atrial-natriuretic peptides; obesity; genetic association; smoking;

    机译：科林;幼心性 - 利可钠肽;肥胖症;遗传学协会;吸烟;

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