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首页> 外文期刊>Journal of Environmental & Analytical Toxicology >Short-Term Exposure to Haze Air Pollution Induces Acute Airway Inflammation and Lung Function Reduction in Healthy Adult Subjects
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Short-Term Exposure to Haze Air Pollution Induces Acute Airway Inflammation and Lung Function Reduction in Healthy Adult Subjects

机译：短期暴露于阴霾空气污染会导致健康成人受试者急性气道炎症和肺功能下降

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Haze air pollution with high levels of PM has frequently took place in many areas of China in the past few years. However, the health effect of shirt-term exposure to haze air pollution has not been thoroughly characterized. This study aimed to determine the acute effect of haze exposure on respiratory system of healthy adult subjects, specifically on airways and lung function. Thirty healthy adult subjects were recruited and airway inflammation and lung function alterations examined under control and haze air pollution (157.33 μg/m for mean concentration of PM ) conditions, respectively. Airway inflammation was assessed by sputum induction while lung function was measured using spirometry. It was shown that 24-h exposure to haze air pollution could increase the levels of inflammatory mediators including interleukin-6 (IL-6), IL-8, and tumor necrotic factor-α (TNF-α), as well as the percentages of eosinophils, neutrophils, and lymphocytes in the sputum (0.05). In contrast, the proportion of macrophages in the sputum from haze-exposed subjects decreased significantly (0.05). In addition, short-term exposure to haze could decrease forced vital capacity (FVC), forced expiratory volume in the first second (FEV ), vital capacity (VC), and maximum voluntary ventilation (MVV), but not FEV1/FVC. In summary, short-term exposure of healthy adult subjects to haze air pollution induces airway inflammation and lung function impairment.
机译：在过去的几年中，中国许多地区经常发生高浓度PM霾空气污染。但是，衬衫衬衫长期暴露于阴霾空气污染的健康影响尚未得到充分表征。这项研究旨在确定雾霾暴露对健康成人受试者呼吸系统的急性影响，特别是对气道和肺功能的影响。招募了30名健康成人受试者，分别在对照和雾霾空气污染（PM的平均浓度为157.33μg/ m2）条件下检查气道炎症和肺功能改变。通过痰诱导评估气道炎症，同时使用肺活量测定法测量肺功能。结果表明，暴露于阴霾空气中24小时会增加炎症介质的水平，包括白介素6（IL-6），IL-8和肿瘤坏死因子-α（TNF-α）以及其百分比痰中嗜酸性粒细胞，嗜中性粒细胞和淋巴细胞的含量（<0.05）。相比之下，暴露于阴霾的受试者的痰中巨噬细胞的比例显着降低（<0.05）。此外，短期暴露于烟雾可能会降低强制肺活量（FVC），第一秒强制呼气量（FEV），肺活量（VC）和最大自愿通气量（MVV），但不会降低FEV1 / FVC。总之，健康成年受试者短期暴露于阴霾空气污染会引起气道炎症和肺功能受损。

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