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首页> 外文期刊>Journal of genetics >The effect of functional compensation among duplicate genes can constrain their evolutionary divergence
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The effect of functional compensation among duplicate genes can constrain their evolutionary divergence

机译：重复基因之间的功能补偿效应可以限制其进化差异

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Gene duplicates have the inherent property of initially being functionally redundant. This means that they can compensate for the effect of deleterious variation occurring at one or more sister sites. Here, I present data bearing on evolutionary theory that illustrates the manner in which any functional adaptation in duplicate genes is markedly constrained because of the compensatory utility provided by a sustained genetic redundancy. Specifically, a two-locus epistatic model of paralogous genes was simulated to investigate the degree of purifying selection imposed, and whether this would serve to impede any possible biochemical innovation. Three population sizes were considered to see if, as expected, there was a significant difference in any selection for robustness. Interestingly, physical linkage between tandem duplicates was actually found to increase the probability of any neofunctionalization and the efficacy of selection, contrary to what is expected in the case of singleton genes. The results indicate that an evolutionary trade-off often exists between any functional change under either positive or relaxed selection and the need to compensate for failures due to degenerative mutations, thereby guaranteeing the reliability of protein production.
机译：基因重复具有最初在功能上多余的固有特性。这意味着它们可以补偿一个或多个姐妹位点发生的有害变异的影响。在这里，我提供有关进化理论的数据，该数据说明了由于持续的遗传冗余提供的补偿效用，重复基因中的任何功能适应都受到显着限制的方式。具体而言，模拟了一个两位同源基因的上位性模型，以研究所进行的纯化选择的程度，以及这是否会阻碍任何可能的生化创新。考虑了三个总体大小，以查看是否在鲁棒性选择上有显着差异。有趣的是，实际上发现串联重复之间的物理联系增加了任何新功能化的可能性和选择的功效，这与单例基因的情况相反。结果表明，在正向选择或宽松选择下的任何功能变化与需要补偿由于简并突变而导致的失败之间，往往存在进化权衡，从而保证了蛋白质生产的可靠性。

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