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首页> 外文期刊>Journal of genetics >Biodiversity and selection for scrapie resistance in sheep: genetic polymorphism in eight breeds of Algeria
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Biodiversity and selection for scrapie resistance in sheep: genetic polymorphism in eight breeds of Algeria

机译：绵羊的耐刮擦性的生物多样性和选择：阿尔及利亚八个品种的遗传多态性

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Scrapie is a prion disease that affects the sheep and goats. It belongs to the group of transmissible spongiform encephalopathies (TSE). TSEs are characterized by the accumulation of the pathological form (PrPSc) of the cellular prion protein ( PrPC). The susceptibility of sheep to scrapie is influenced by polymorphisms in the PrP gene (PRNP). The aim of this study was to identify the genetic variability of sheep PRNP in Algerian sheep. Two-hundred and thirteen Algerian sheep from eight breeds (Ouled Djellal, Rembi, Hamra, Berbere, Barbarine, Sidaou, Taadmit and Tazegzawt) with no clinical manifestation of scrapie were analysed. Sequencing of the entire coding sequence of PRNP showed four main alleles (ARQ, ARR, AHQ and ARH) based on codons 136, 154 and 171 with different frequencies among the investigated breeds. Moreover, 14 additional nonsynonymous polymorphisms (Q101R, N103K, M112T, A116P, M137I, L141F, I142M, H143R, N146S, R151G, Y172D, N176K, H180Y and S240P) as well as two synonymous polymorphisms at codons 231 and 237 were found in the PRNP gene. Interestingly, the N103K, M137I and I142M polymorphisms were not described in sheep. The ARQ, ARR and ARH haplotypes were present in all breeds with a highest frequency of ARQ in Barbarine. The ARH was absent in Barbarine breed and the VRQ haplotype was absent in all Algerian breeds studied. The ARQ and ARR alleles were the most common with frequencies ranging from 30 to 65% and from 8 to 26%, respectively, in different breeds. These results represent the first study on PRNP variability in Algerian sheep and may serve as a basis for the development of breeding programmes to render national sheep breeds resistant to scrapie.
机译：rap痒病是一种ion病毒疾病，会影响绵羊和山羊。它属于传染性海绵状脑病（TSE）组。 TSE的特征是细胞病毒蛋白（PrPC）的病理形式（PrPSc）积累。绵羊对瘙痒病的易感性受PrP基因（PRNP）多态性的影响。这项研究的目的是确定阿尔及利亚绵羊PRNP的遗传变异。分析了八种不同品种的213头阿尔及利亚绵羊（Ouled Djellal，Rembi，Hamra，Berbere，Barbarine，Sidaou，Taadmit和Tazegzawt），这些动物没有瘙痒病的临床表现。 PRNP整个编码序列的测序表明，在所研究的品种中，基于密码子136、154和171的四个主要等位基因（ARQ，ARR，AHQ和ARH）的频率不同。此外，在该密码子中还发现了14个其他非同义多态性（Q101R，N103K，M112T，A116P，M137I，L141F，I142M，H143R，N146S，R151G，Y172D，N176K，H180Y和S240P）以及两个同义多态性。 PRNP基因。有趣的是，在绵羊中没有描述N103K，M137I和I142M多态性。在所有品种中，ARQ，ARR和ARH单倍型均存在，Barbarine中ARQ的频率最高。 Barbarine品种中没有ARH，所有阿尔及利亚品种中都没有VRQ单倍型。在不同品种中，ARQ和ARR等位基因最常见，频率分别为30％至65％和8％至26％。这些结果代表了对阿尔及利亚绵羊PRNP变异性的首次研究，并且可以作为制定育种计划的基础，以使本国绵羊品种具有耐刮擦性。

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