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Biodiversity and selection for scrapie resistance in sheep: genetic polymorphism in eight breeds of Algeria

机译：绵羊剥落抗性的生物多样性和选择：八种阿尔及利亚遗传多态性

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Scrapie is a prion disease that affects the sheep and goats. It belongs to the group of transmissible spongiform encephalopathies (TSE). TSEs are characterized by the accumulation of the pathological form (PrPSc) of the cellular prion protein (PrPC). The susceptibility of sheep to scrapie is influenced by polymorphisms in the PrP gene (PRNP). The aim of this study was to identify the genetic variability of sheep PRNP in Algerian sheep. Two-hundred and thirteen Algerian sheep from eight breeds (Ouled Djellal, Rembi, Hamra, Berbere, Barbarine, Sidaou, Taadmit and Tazegzawt) with no clinical manifestation of scrapie were analysed. Sequencing of the entire coding sequence of PRNP showed four main alleles (ARQ, ARR, AHQ and ARH) based on codons 136, 154 and 171 with different frequencies among the investigated breeds. Moreover, 14 additional nonsynonymous polymorphisms (Q101R, N103K, M112T, A116P, M137I, L141F, I142M, H143R, N146S, R151G, Y172D, N176K, H180Y and S240P) as well as two synonymous polymorphisms at codons 231 and 237 were found in the PRNP gene. Interestingly, the N103K, M137I and I142M polymorphisms were not described in sheep. The ARQ, ARR and ARH haplotypes were present in all breeds with a highest frequency of ARQ in Barbarine. The ARH was absent in Barbarine breed and the VRQ haplotype was absent in all Algerian breeds studied. The ARQ and ARR alleles were the most common with frequencies ranging from 30 to 65% and from 8 to 26%, respectively, in different breeds. These results represent the first study on PRNP variability in Algerian sheep and may serve as a basis for the development of breeding programmes to render national sheep breeds resistant to scrapie.
机译：Scrapie是一种影响绵羊和山羊的朊病毒疾病。它属于可传染性海绵状脑病（TSE）组。 TSES的特征在于细胞朊病毒蛋白（PRPC）的病理形式（PRPSC）的积累。绵羊对斯基因的敏感性受PRP基因（PRNP）中多态性的影响。本研究的目的是识别阿尔及利亚羊的绵羊PRNP的遗传变异。分析了来自八种品种（Ouled Djellal，Rembi，Hamra，Berbere，Barbarine，Sidaou，Taadmit和Tazegzawt）的两百和十三名阿尔及利亚羊，没有临床表现出来。 PRNP的整个编码序列的测序显示了基于Codons 136,154和171的四个主要等位基因（ARQ，ARR，AHQ和ARH），其中调查的品种中的不同频率。此外，14个另外的非纯多态性（Q101R，N103K，M112T，A116P，M137I，L141F，I142M，H143R，N146S，R151G，Y172D，N176K，H180Y和S240P）以及密码子231和237处的两个同义多态性PRNP基因。有趣的是，N103K，M137I和I142M多态性未在绵羊中描述。 ARQ，ARR和ARH单倍型在所有品种中存在于律栏中的最高频率的品种中。 ARH在伯巴丁繁殖中缺席，所有在研究的阿尔及利亚品种中没有VRQ单倍型。 ARQ和ARR等位基因最常见，频率分别为30％至65％，分别为8-26％，以不同的品种。这些结果代表了阿尔及利亚羊的PRNP变异性的第一研究，可以作为发展育种计划的养殖计划的基础，使国家绵羊滋生抗瘙痒病。

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