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首页> 外文期刊>Journal of genetics >Tumour necrosis factor alpha (TNF-e???) genetic polymorphisms and the risk of autoimmune liver disease: a meta-analysis
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Tumour necrosis factor alpha (TNF-e???) genetic polymorphisms and the risk of autoimmune liver disease: a meta-analysis

机译：肿瘤坏死因子α（TNF-e ???）遗传多态性和自身免疫性肝病的风险：荟萃分析

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Epidemiological studies have evaluated the association between tumour necrosis factor alpha (TNF-e???)-308G/A and (TNF-e???)-238G/A polymorphisms, and the risk of autoimmune liver disease (AILD), yet the results are conflicting. To derive a more precise estimation of the relationship, we performed this meta-analysis. A systematic review was conducted to identify all eligible studies of TNF-e??? polymorphisms and AILD risk. We used odds ratios (ORs) with 95% confidence intervals (CIs) to assess the strength of the association between the two TNF-e??? polymorphisms and AILD risk. A total of 15 eligible studies were identified. Overall, positive associations of -308G/A polymorphism with AILD risk were found (A vs G allele: OR = 1.45, 95%,CI = 1.13a€“1.86; AA vs GG: OR = 2.74, 95%,CI = 1.51a€“4.96; GA vs GG: OR = 1.46, 95%,CI = 1.11a€“1.92; dominant model: OR = 1.57, 95%,CI = 1.18a€“2.10; recessive model: OR = 2.22, 95%,CI = 1.31a€“3.76). In subgroup analysis by ethnicity, a significantly higher risk was found in Caucasians. In subgroup analysis by AILD category, significant association was observed in autoimmune hepatitis and primary sclerosing cholangitis, especially in Caucasians. Patients carrying TNF-e???-238A allele had a slightly decreased risk of developing AILD (OR = 0.65, 95%,CI = 0.48a€“0.87). However, we found both TNF-e??? polymorphisms were not associated with primary biliary cirrhosis risk, even in subgroup analysis. Our metaanalysis suggests that the TNF-e???-308G/A and -238G/A polymorphisms may contribute to AILD susceptibility in Caucasians, especially for autoimmune hepatitis and primary sclerosing cholangitis. Nevertheless, we found both TNF-e??? polymorphisms were unlikely to be associated with the risk of primary biliary cirrhosis.
机译：流行病学研究评估了肿瘤坏死因子α（TNF-e ???）-308G / A和（TNF-e ???）-238G / A多态性与自身免疫性肝病（AILD）风险之间的关系结果是矛盾的。为了获得更精确的关系估计，我们进行了这项荟萃分析。进行了系统的审查，以确定所有合格的TNF-e研究。多态性和AILD风险。我们使用具有95％置信区间（CI）的比值比（OR）来评估两个TNF-e之间的关联强度。多态性和AILD风险。总共鉴定了15项合格研究。总体上，发现-308G / A多态性与AILD风险呈正相关（A与G等位基因：OR = 1.45，95％，CI = 1.13a-1.86; AA与GG：OR = 2.74，95％，CI = 1.51 4.96; GA与GG：OR = 1.46，95％，CI = 1.11a 1.92;优势模型：OR = 1.57，95％，CI = 1.18a 2.10;隐性模型：OR = 2.22，95 ％，CI ＝ 1.31a-“ 3.76）。在按种族进行的亚组分析中，高加索人的风险明显更高。在按AILD分类的亚组分析中，在自身免疫性肝炎和原发性硬化性胆管炎中观察到显着相关性，尤其是在白种人中。携带TNF-e ???-238A等位基因的患者患AILD的风险略有降低（OR = 0.65，95％，CI = 0.48a±0.87）。但是，我们发现了两种TNF-e ？？？即使在亚组分析中，多态性也与原发性胆汁性肝硬化风险无关。我们的荟萃分析表明，TNF-eβ-308G/ A和-238G / A多态性可能导致高加索人的AILD易感性，特别是对于自身免疫性肝炎和原发性硬化性胆管炎。然而，我们发现了两种TNF-e ？？？多态性不太可能与原发性胆汁性肝硬化的风险有关。

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