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首页> 外文期刊>Journal of Ginseng Research >The psychopharmacological activities of Vietnamese ginseng in mice: characterization of its psychomotor, sedative–hypnotic, antistress, anxiolytic, and cognitive effects
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The psychopharmacological activities of Vietnamese ginseng in mice: characterization of its psychomotor, sedative–hypnotic, antistress, anxiolytic, and cognitive effects

机译：越南人参在小鼠中的心理药理活性：其心理运动，镇静催眠，抗应激，抗焦虑和认知作用的表征

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Background Panax vietnamensis Ha et Grushv. or Vietnamese ginseng (VG) is a recently discovered ginseng species. Studies on its chemical constituents have shown that VG is remarkably rich in ginseng saponins, particularly ocotillol saponins. However, the psychopharmacological effects of VG have not been characterized. Thus, in the present study we screened the psychopharmacological activities of VG in mice. Methods VG extract (VGE) was orally administered to mice at various dosages to evaluate its psychomotor (open-field and rota-rod tests), sedative–hypnotic (pentobarbital-induced sleeping test), antistress (cold swimming test), anxiolytic (elevated plus-maze test), and cognitive (Y-maze and passive-avoidance tests) effects. Results VGE treatment increased the spontaneous locomotor activity, enhanced the endurance to stress, reduced the anxiety-like behavior, and ameliorated the scopolamine-induced memory impairments in mice. In addition, VGE treatment did not alter the motor balance and coordination of mice and did not potentiate pentobarbital-induced sleep, indicating that VGE has no sedative-hypnotic effects. The effects of VGE were comparable to those of the Korean Red Ginseng extract. Conclusion VG, like other ginseng products, has significant and potentially useful psychopharmacological effects. This includes, but is not limited to, psychomotor stimulation, anxiolytic, antistress, and memory enhancing effects. Keywords: antifatigue, memory, Panax vietnamensis , psychopharmacological activity, Vietnamese ginseng.
机译：背景越南人参Ha et Grushv。越南人参（VG）是最近发现的人参种类。关于其化学成分的研究表明，VG富含人参皂苷，尤其是奥考替洛皂苷。但是，VG的心理药理作用尚未明确。因此，在本研究中，我们筛选了小鼠中VG的心理药理活性。方法以不同剂量向小鼠口服VG提取物（VGE），以评估其精神运动（开放视野和旋转棒测试），镇静-催眠（戊巴比妥诱发的睡眠测试），抗应激（冷游泳测试），抗焦虑（升高）加迷宫测试）和认知（Y迷宫和被动回避测试）效果。结果VGE处理可增加小鼠的自发运动能力，增强其承受压力的能力，减轻其焦虑样行为，并减轻东pol碱所致小鼠的记忆障碍。此外，VGE治疗没有改变小鼠的运动平衡和协调性，也没有增强戊巴比妥诱发的睡眠，表明VGE没有镇静催眠作用。 VGE的效果与韩国红参提取物相当。结论VG与其他人参产品一样，具有重要且潜在有用的心理药理作用。这包括但不限于精神运动刺激，抗焦虑，抗应激和记忆增强作用。关键词：抗疲劳，记忆力，越南人参，心理药理活性，越南人参。

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