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首页> 外文期刊>Journal of Experimental Neuroscience >An Integrative Approach to Neuroinflammation in Psychiatric disorders and Neuropathic Pain:
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An Integrative Approach to Neuroinflammation in Psychiatric disorders and Neuropathic Pain:

机译：精神疾病和神经性疼痛中神经炎症的综合方法：

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摘要

Neuroinflammation is a complex process involving both the peripheral circulation and the Central Nervous System (CNS) and is considered to underlie many CNS disorders including depression, anxiety, schizophrenia, and pain. Stressors including early-life adversity, psychosocial stress, and infection appear to prime microglia toward a pro-inflammatory phenotype. Subsequent inflammatory challenges then drive an exaggerated neuroinflammatory response involving the upregulation of pro-inflammatory mediators that is associated with CNS dysfunction. Several pharmacologic inhibitors of pro-inflammatory cytokines including TNF-α and IL-1β show good clinical efficacy in terms of ameliorating neuroinflammatory processes. Mind/body and plant-based interventions such as yoga, breathing exercises, meditation, and herbs/spices have also been demonstrated to reduce pro-inflammatory cytokines and have a positive impact on depression, anxiety, cognition, and pain. As the intricate connections between the immune system and the nervous system continue to be elucidated, successful therapies for reducing neuroinflammation will likely involve an integrated approach combining drug therapy with nonpharmacologic interventions.
机译：神经炎症是一个复杂的过程，涉及外周循环和中枢神经系统（CNS），被认为是许多中枢神经系统疾病的基础，包括抑郁症，焦虑症，精神分裂症和疼痛。包括早年逆境，社会心理压力和感染在内的压力源似乎使小胶质细胞趋向于促炎表型。然后，随后的炎症挑战会引发过度的神经炎症反应，涉及与CNS功能障碍相关的促炎介质的上调。就减轻神经炎性过程而言，包括TNF-α和IL-1β在内的几种促炎性细胞因子的药理抑制剂表现出良好的临床疗效。还证实了基于心理/身体和植物的干预措施，例如瑜伽，呼吸运动，冥想和草药/香料，可以减少促炎性细胞因子，并对抑郁，焦虑，认知和疼痛产生积极影响。随着免疫系统和神经系统之间复杂关系的不断阐明，减少神经炎症的成功疗法可能涉及将药物治疗与非药物干预相结合的综合方法。

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