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首页> 外文期刊>Journal of Hainan Medical University >Effect of ticagrelor and clopidogrel on serum inflammatory factor level in antiplatelet therapy for acute myocardial infarction patients after percutaneous coronary intervention
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Effect of ticagrelor and clopidogrel on serum inflammatory factor level in antiplatelet therapy for acute myocardial infarction patients after percutaneous coronary intervention

机译：替卡格雷和氯吡格雷对经皮冠状动脉介入治疗后急性心肌梗死患者抗血小板治疗中血清炎性因子水平的影响

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Objective: To compare the effect of ticagrelor and clopidogrel on serum inflammatory factorlevel in antiplatelet therapy for acute myocardial infarction (AMI) patients after percutaneouscoronary intervention (PCI). Methods: 113 cases of AMI underwent PCI in our hospital fromMarch 2016 to February 2018 were selected and divided into two groups. The experimentalgroup (n=58) received the ticagrelor, while the control group (n=55) received the clopidogrel.Then the platelet aggregation, serum inflammatory factors, liver and kidney function, andcardiovascular and cerebrovascular events at the post 6-mon follow-up were compared betweengroups. Results: The platelet aggregation rate had no difference between the two groups beforePCI (P0.05), which were higher in the control group than in the experimental group at thepost-PCI 24 h and 7 d (P0.05), whichwere higher in the control group than in the experimental group at the post-PCI 24 h and 7 d(P0.05). The serum creatinine (Scr) levels hadno difference between the two groups before PCI (P0.05), which were lower in the controlgroup than in the experimental group at the post-PCI 24 h and 7 d (P0.05). The incidence rateof the cardiovascular and cerebrovascular events at the post 6-months follow-up of the controlgroup was higher than that of the experimental group [14.55% (8/55) vs 5.17% (3/58), P0.05].Conclusion: Compared with the clopidogrel treatment, the application of ticagrelor has abetter effect in antiplatelet therapy for AMI patients underwent PCI, which can effectivelycontrol serum inflammatory factor levels, stabilize liver function, reduce the occurrence ofcardiovascular and cerebrovascular events, and improve the prognosis.
机译：目的：比较替卡格雷和氯吡格雷对经皮冠状动脉介入治疗（PCI）后急性心肌梗死（AMI）患者抗血小板治疗的血清炎性因子水平的影响。方法：选择2016年3月至2018年2月在我院行PCI的AMI患者113例，分为两组。实验组（n = 58）接受替卡格雷治疗，而对照组（n = 55）接受氯吡格雷治疗。随后6个月后随访，血小板聚集，血清炎性因子，肝肾功能以及心血管和脑血管事件组之间进行比较。结果：PCI前两组之间的血小板聚集率无差异（P> 0.05），对照组在PCI后24 h和7 d时血小板聚集率高于实验组（P0.05），而在PCI后7天（P​​0.05）较高。 PCI后24 h和7 d，对照组比实验组好（P0.05）。两组PCI前血清肌酐（Scr）水平无差异（P> 0.05），而在PCI后24 h和7 d，对照组的肌酐水平低于实验组（P <0.05）。对照组随访6个月后心脑血管事件的发生率高于实验组[14.55％（8/55）vs 5.17％（3/58），P <0.05]。结论：与氯吡格雷治疗相比，替卡格雷对PCI的AMI患者抗血小板治疗效果更好，可有效控制血清炎症因子水平，稳定肝功能，减少心脑血管事件的发生，改善预后。

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