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首页> 外文期刊>Journal of immunology research. >Uncomplicated Diverticular Disease: Innate and Adaptive Immunity in Human Gut Mucosa before and after Rifaximin
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Uncomplicated Diverticular Disease: Innate and Adaptive Immunity in Human Gut Mucosa before and after Rifaximin

机译：单纯性憩室病：利福昔明前后人类肠道粘膜的先天性和适应性免疫

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Background/Aim. Uncomplicated diverticular disease (UDD) is a frequent condition in adults. The pathogenesis of symptoms remains unknown. Bacteria are able to interact with Toll-like receptors (TLRs) and to induce inflammation through both innate immunity and T-cell recruitment. We investigated the pattern of TLRs 2 and 4 and the intestinal homing in patients with UDD before and after a course of Rifaximin. Methods. Forty consecutive patients with UDD and 20 healthy asymptomatic subjects were enrolled. Among UDD patients, 20 were assigned to a 2-month course of treatment with Rifaximin 1.2 g/day for 15 days/month and 20 received placebo. Blood sample and colonic biopsies were obtained from patients and controls. The samples were collected and analyzed at baseline and at the end of treatment. Flow cytometry was performed using monoclonal antibodies (CD3, CD4, CD8, CD103, TCR-gamma/delta, CD14, TLR2, and TLR4). Results. In UDD, TLR2 and TLR4 expression on immune cell subpopulations from blood and mucosa of the affected colon are altered as compared with controls. Rifaximin treatment induced significant modifications of altered conditions. Conclusions. Our data show the role of TLRs in the development of inflammation in UDD. TLRs distribution is altered in UDD and these alterations are reversed after antibiotic treatment. This trial is registered with ClinicalTrials.gov NCT02068482.
机译：背景/目标。单纯性憩室病（UDD）是成年人的常见病。症状的发病机理仍然未知。细菌能够与Toll样受体（TLR）相互作用，并通过先天免疫和T细胞募集而诱发炎症。我们调查了利福昔明治疗前后UDR患者的TLR 2和4的模式以及肠归巢情况。方法。连续入选40例UDD患者和20名健康无症状受试者。在UDD患者中，有20名被分配为用利福昔明1.2微克/天进行2个月的疗程，持续15天/月，还有20名接受了安慰剂。从患者和对照中获得血液样本和结肠活检。在基线和治疗结束时收集并分析样品。使用单克隆抗体（CD3，CD4，CD8，CD103，TCR-γ/δ，CD14，TLR2和TLR4）进行流式细胞仪。结果。在UDD中，与对照组相比，受影响结肠的血液和粘膜中免疫细胞亚群上的TLR2和TLR4表达发生了变化。利福昔明治疗引起条件改变的显着改变。结论。我们的数据显示了TLRs在UDD发炎中的作用。在UDD中TLR的分布发生了变化，经过抗生素治疗后这些变化被逆转。该试验已在ClinicalTrials.gov NCT02068482上注册。

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