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首页> 外文期刊>Journal of immunology research. >Exploring Systemic Autoimmunity in Thyroid Disease Subjects
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Exploring Systemic Autoimmunity in Thyroid Disease Subjects

机译：探索甲状腺疾病受试者的全身自身免疫

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Introduction. Individuals with one autoimmune disease are at risk of developing a second autoimmune disease, but the pathogenesis or the sequential occurrence of multiple autoimmune diseases has not been established yet. In this study, we explored the association and sequential occurrence of antibodies in thyroid disease and systemic autoimmune disease subjects. We evaluated thyroid hormones, thyroid-stimulating hormone (TSH), free thyroxine (FT4), thyroid autoantibodies, anti-thyroperoxidase (anti-TPO), and anti-thyroglobulin (Tg) to comprehend the association with systemic autoimmune autoantibodies, anti-nuclear antibodies (ANA), and autoantibodies to extractable nuclear antigens (ENA) in subjects with thyroid-related symptoms. Methods. A total of 14825 subjects with thyroid-related symptoms were tested at Vibrant America Clinical Laboratory for thyroid markers (TSH, FT4, anti-TPO, and anti-Tg) and an autoimmune panel (ANA panel and ENA-11 profile) from March 2016 to May 2018. Thyroid-positive (based on TSH and FT4 levels), anti-TPO-positive, and anti-Tg-positive subjects were assessed for the prevalence of ANA and anti-ENA antibodies. A 2-year follow-up study was conducted to assess the sequential order of appearance of autoimmune markers in thyroid and systemic autoimmune diseases. Results. In the retrospective analysis, 343/1671 (20.5%), 2037/11235 (18.1%), and 1658/9349 (17.7%) of thyroid
机译：介绍。具有一种自身免疫性疾病的个体有患第二种自身免疫性疾病的风险，但是尚未确定多种自身免疫性疾病的发病机理或顺序发生。在这项研究中，我们探讨了甲状腺疾病和全身自身免疫性疾病受试者中抗体的关联和顺序发生。我们评估了甲状腺激素，促甲状腺激素（TSH），游离甲状腺素（FT4），甲状腺自身抗体，抗甲状腺素氧化酶（anti-TPO）和抗甲状腺球蛋白（Tg），以了解与全身性自身免疫性自身抗体，抗核素的关联甲状腺相关症状的受试者体内的抗体（ANA）和针对可提取核抗原（ENA）的自身抗体。方法。自2016年3月起，在充满活力的美国临床实验室共对14825名患有甲状腺相关症状的受试者进行了甲状腺标志物（TSH，FT4，抗TPO和抗Tg）和自身免疫检测（ANA检测和ENA-11检测）测试至2018年5月。评估了甲状腺阳性（基于TSH和FT4水平），抗TPO阳性和抗Tg阳性受试者的ANA和抗ENA抗体的患病率。进行了为期2年的随访研究，以评估甲状腺和全身性自身免疫疾病中自身免疫标记物出现的顺序。结果。在回顾性分析中，甲状腺的343/1671（20.5％），2037/11235（18.1％）和1658/9349（17.7％）

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