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首页> 外文期刊>Journal of Hainan Medical University >Effect of kanglaite injection and docetaxel in treating advanced stage esophageal cancer on tumor markers, angiogenesis and immune function in elderly patients
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Effect of kanglaite injection and docetaxel in treating advanced stage esophageal cancer on tumor markers, angiogenesis and immune function in elderly patients

机译：康莱特注射液和多西他赛治疗晚期食管癌对老年患者肿瘤标志物，血管生成和免疫功能的影响

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Objective: To investigate the effect of Kanglaite injection combined with docetaxel in advanced esophageal cancer on tumor markers, angiogenesis and immune function in elderly patients. Method: A total of 130 patients with advanced esophageal cancer admitted in our hospital from October 2014 to July 2017were selected and divided into two groups according to the time of admission, 65 cases in each group, set as observation group and control group, all patients were treated with conventional radiotherapy (cisplatin combined with 5-fluorouracil), the observation group was given Kanglaite injection combined with docetaxel on the basis of this, while the control group only was given docetaxel treatment, the treatment period was 6 weeks, tumor markers, VEGF and immune function of both group after treatment were compared. Result: After treatment, the levels of carbohydrate antigen 125 (CA125), carbohydrate antigen 19-9 (CA19-9) and carcino-embryonic antigen (CEA) in the observation group were lower than those in the control group, the difference was statistically significant; VEGF level in the observation group after treatment was lower than the control group, the difference was statistically significant; After treatment, the levels of CD3+, CD4+ and CD4+/ CD8+ in the observation group were higher than those in the control group, while the levels of CD8+ in the observation group was lower than those in the control group, the difference was statistically significant. Conclusion: Kanglaite injection combined with docetaxel in the treatment of elderly patients with advanced esophageal cancer is better, effectively reducing the level of tumor markers and vascular endothelial growth factor, improve immune function, it isworthy of clinical application.
机译：目的：探讨康莱特注射液联合多西他赛治疗晚期食管癌对老年患者肿瘤标志物，血管生成和免疫功能的影响。方法：选择我院2014年10月至2017年7月收治的130例晚期食管癌患者，按入院时间分为两组，每组65例，分别作为观察组和对照组，全部患者常规放疗（顺铂联合5-氟尿嘧啶）治疗，观察组在此基础上给予康莱特注射液联合多西他赛治疗，对照组仅给予多西他赛治疗，治疗时间为6周，肿瘤标志物，比较两组治疗后的VEGF和免疫功能。结果：观察组治疗后碳水化合物抗原125（CA125），碳水化合物抗原19-9（CA19-9）和癌胚抗原（CEA）水平低于对照组，差异有统计学意义重大;观察组治疗后VEGF水平低于对照组，差异有统计学意义;治疗后，观察组的CD3 +，CD4 +和CD4 + / CD8 +的水平高于对照组，而观察组的CD8 +的水平低于对照组，差异有统计学意义。结论：康莱特注射液联合多西他赛治疗老年晚期食管癌较好，可有效降低肿瘤标志物和血管内皮生长因子水平，提高免疫功能，值得临床应用。

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