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首页> 外文期刊>Journal of Hainan Medical University >Effect of dexmedetomidine pretreatment on postoperative immune function and inflammatory stress response in patients with non-small cell lung cancer surgery
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Effect of dexmedetomidine pretreatment on postoperative immune function and inflammatory stress response in patients with non-small cell lung cancer surgery

机译：右美托咪定预处理对非小细胞肺癌手术患者术后免疫功能和炎症应激反应的影响

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Objective: To study the effect of dexmedetomidine pretreatment on postoperative immune function and inflammatory stress response in patients with non-small cell lung cancer surgery. Methods: Patients with non-small cell lung cancer who underwent radical operation for lung cancer in Xi'an Aerospace General Hospital between August 2014 and September 2017 were selected and randomly divided into the Dex group who received dexmedetomidine pretreatment combined with general anesthesia and the control group who received routine general anesthesia. The same day after surgery and 3 d after surgery, the peripheral blood was collected respectively to determine the contents of immune cells and the serum was collected respectively to determine the contents of inflammatory stress response indexes. Results: The same day after surgery and 3 d after surgery, CD3 + CD4 + T cell, CD3 + CD8 + T cell and CD16 + CD56 + NK cell contents in peripheral blood of Dex group were significantly higher than those of control group whereas CD11b + CD15 + CD33 + CD14 - G-MDSC, CD11b + CD15 - CD33 + CD14 + M-MDSC and CD4 + CD25 + CD127lowTreg contents in peripheral blood as well as TNF-α, SAA, CRP, IL-8, IL-10, Cor, Ins, NE, E and AT-II contents in serum were significantly lower than those of control group. Conclusion: Dexmedetomidine pretreatment can improve the immune function and inhibit the inflammatory stress response in patients with non-small cell lung cancer surgery.
机译：目的：研究右美托咪定预处理对非小细胞肺癌手术患者术后免疫功能和炎症应激反应的影响。方法：选择2014年8月至2017年9月在西安航空航天总医院接受肺癌根治性手术的非小细胞肺癌患者，随机分为右美托咪定联合全身麻醉和对照的Dex组。接受常规全身麻醉的组。术后第2天和术后第3天，分别采集外周血以测定免疫细胞的含量，并采集血清以测定炎症应激反应指标的含量。结果：Dex组患者外周血CD3 + CD4 + T细胞，CD3 + CD8 + T细胞和CD16 + CD56 + NK细胞的含量明显高于对照组，而CD11b明显高于对照组。 +外周血中CD15 + CD33 + CD14-G-MDSC，CD11b + CD15-CD33 + CD14 + M-MDSC和CD4 + CD25 + CD127lowTreg含量以及TNF-α，SAA，CRP，IL-8，IL-10血清中Cor，Ins，NE，E和AT-II的含量均明显低于对照组。结论：右美托咪定预处理可改善非小细胞肺癌手术患者的免疫功能并抑制炎症应激反应。

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