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首页> 外文期刊>Journal of Hainan Medical University >Effect of Shenkang granule combined with Atorvastatin on renal function, urinary protein and coagulation function in patients with chronic nephritis
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Effect of Shenkang granule combined with Atorvastatin on renal function, urinary protein and coagulation function in patients with chronic nephritis

机译：肾康颗粒联合阿托伐他汀对慢性肾炎患者肾功能，尿蛋白和凝血功能的影响

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Objective: To investigate the effect of Shenkang granule combined with Atorvastatin on renal function, urinary protein and coagulation function in patients with chronic nephritis. Methods: A total of 100 patients with chronic nephritis who were treated in our hospital between May 2016 to May 2017 were randomly divided into control group and observation group, 50 cases in each group. Patients in the control group were treated with Atorvastatin, while patients in the observation group were treated with Shenkang granule on the basis of the treatment in the control group. The changes of renal function, coagulation function and inflammatory factors were detected and compared between the patients in the two groups before and after treatment. Result: After treatment, the levels of Cr, BUN and 24hUpro in serum of patients in the two groups were significantly decreased, and the levels of ALB were significantly increased, and the changes of the above factors of patients in the observation group were more obvious. After treatment, the levels of PT, APTT and TT of patients in the two groups were significantly increased, and the levels of FIB were significantly decreased, and the changes of the above indexes of patients in the observation group were more obvious. After treatment, the levels of hs-CRP and TNF-α in serum of patients in the two groups were significantly decreased, and the decrease trend of inflammatory factors of patients in the observation group was more obvious. Conclusion: Shenkang granule combined with Atorvastatin has a good effect on treatment of chronic nephritis. It can significantly improve renal function and coagulation function, alleviate inflammation, and has a certain protective effect on kidney of patients.
机译：目的：探讨肾康颗粒联合阿托伐他汀对慢性肾炎患者肾功能，尿蛋白和凝血功能的影响。方法：将2016年5月至2017年5月在我院接受治疗的100例慢性肾炎患者随机分为对照组和观察组，每组50例。对照组患者用阿托伐他汀治疗，观察组患者在对照组的基础上用神康颗粒治疗。观察两组患者治疗前后肾脏功能，凝血功能和炎症因子的变化，并进行比较。结果：治疗后，两组患者血清中Cr，BUN和24hUpro水平显着降低，ALB水平显着升高，观察组患者上述因素变化更明显。治疗后，两组患者的PT，APTT和TT水平明显升高，FIB水平明显降低，观察组患者上述各项指标的变化更为明显。治疗后，两组患者血清hs-CRP和TNF-α水平明显降低，观察组患者炎症因子降低趋势更明显。结论：肾康颗粒联合阿托伐他汀治疗慢性肾炎疗效确切。能显着改善肾脏功能和凝血功能，减轻炎症反应，对患者肾脏有一定的保护作用。

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