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首页> 外文期刊>Journal of Hainan Medical University >Effect of Yanhuning in combined with azithromycin on the inflammatory cytokines and immunological function in children with mycoplasma pneumonia
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Effect of Yanhuning in combined with azithromycin on the inflammatory cytokines and immunological function in children with mycoplasma pneumonia

机译：盐浑宁联合阿奇霉素对支原体肺炎患儿炎性细胞因子及免疫功能的影响

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Objective: To explore the effect of Yanhuning in combined with azithromycin on theinflammatory cytokines and immunological function in children with mycoplasma pneumonia.Methods: A total of 130 children with mycoplasma pneumonia were included in the studyand randomized into the treatment group (n=65) and the control group (n=65). The patients inthe control group were given azithromycin. On the above basis, the patients in the treatmentgroup were given Yanhuning. The patients in the two groups were continuously treated for 7d. The levels of serum inflammatory cytokines and immunological function indicators beforeand after treatment in the two groups were detected and compared. Results: When comparedwith before treatment, the serum IL-2 level after treatment in the two groups was significantlyelevated, while IL-4, IL-10, IL-13, IL-6, TNF-α, and IFN-γ levels were significantlyreduced; moreover, the improvement in the treatment group was significantly superior to that inthe control group. When compared with before treatment, CD3+, CD4+, and CD4+/CD8+ aftertreatment in the two groups were significantly elevated, and those in the treatment group weresignificantly higher than those in the control group, while CD8+ was significantly reduced,but the comparison between the two groups was not statistically significant. When comparedwith before treatment, RBC-C3bR after treatment in the two groups was significantly elevated,while RBC-ICR was significantly reduced; moreover, the improvement in the treatment groupwas significantly superior to that in the control group. Conclusions: Yanhuning in combinedwith azithromycin in the treatment of mycoplasma pneumonia in children can significantlyenhance the immunological function, and reduce the inflammatory reaction, with an effectsignificantly superior to that by single application of azithromycin.
机译：目的：探讨延胡宁联合阿奇霉素对支原体肺炎患儿炎性细胞因子和免疫功能的影响。方法：将130例支原体肺炎患儿纳入研究，随机分为治疗组（n = 65）和对照组。对照组（n = 65）。对照组患者给予阿奇霉素。在此基础上，对治疗组患者进行了盐浑宁治疗。两组患者均连续治疗7d。检测并比较两组治疗前后的血清炎性细胞因子水平和免疫功能指标。结果：与治疗前相比，两组治疗后血清IL-2水平明显升高，而IL-4，IL-10，IL-13，IL-6，TNF-α和IFN-γ水平明显降低。 ;此外，治疗组的改善明显优于对照组。与治疗前相比，两组治疗后CD3 +，CD4 +和CD4 + / CD8 +显着升高，治疗组显着高于对照组，而CD8 +显着降低，但两者比较各组之间无统计学意义。与治疗前相比，两组治疗后RBC-C3bR显着升高，而RBC-ICR显着降低。此外，治疗组的改善明显优于对照组。结论：炎浑宁联合阿奇霉素治疗小儿支原体肺炎可明显增强免疫功能，减少炎症反应，效果明显优于单用阿奇霉素。

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