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首页> 外文期刊>Journal of innovative optical health sciences >TAXOL INDUCES CELL DEATH WITH CYTOPLASM VACUOLIZATION IN PARAPTOSIS-LIKE BUT NOT ONCOSIS FASHION IN ASTC-a-1 CELLS
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TAXOL INDUCES CELL DEATH WITH CYTOPLASM VACUOLIZATION IN PARAPTOSIS-LIKE BUT NOT ONCOSIS FASHION IN ASTC-a-1 CELLS

机译：紫杉醇可在象麻痹一样的细胞分裂中诱导细胞死亡，但在ASTC-a-1细胞中却不致癌

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Recently, we found that high concentration of taxol (70 μM) induced cell death with cytoplasm vacuolization, the typical characteristic of both paraptosis and oncosis, in human lung carcinoma (ASTC-a-1) cells. This report was designed to further determine the form of taxol-induced cell death with cytoplasm vacuolization. It is generally considered that the cytoplasm vacuolization in oncosis due to the swelling of endoplasmic reticulum (ER), mitochondria, lysosomes and nuclei occurs after the loss of mitochondrial membrane potential (ΔΨm). However, flow cytometry (FCM) analysis showed that taxol-induced cytoplasm vacuolization preceded the loss of ΔΨm. Moreover, taxol treatment did not induce the collapse of microtubule, the typical characteristic of oncosis. These data demonstrated that taxol-induced cell death with cytoplasm vacuolization is not oncosis. FCM analysis by Annexin V-FITC/PI apoptosis detection kit further demonstrated that taxol-induced cell death with cytoplasm vacuolization is not apoptos...
机译：最近，我们发现高浓度的紫杉醇（70μM）在人肺癌（ASTC-a-1）细胞中伴随细胞质空泡化而发生细胞死亡，胞质空化是伞形变和肿瘤化的典型特征。该报告旨在进一步确定紫杉醇诱导的细胞质空泡死亡的形式。通常认为，由于线粒体膜电位（ΔΨm）的丧失，由于内质网（ER），线粒体，溶酶体和细胞核的肿胀而在肿瘤中发生细胞质空泡化。然而，流式细胞仪（FCM）分析表明，紫杉醇诱导的细胞质空泡作用先于ΔΨm的损失。此外，紫杉醇治疗没有引起微管的塌陷，微管是肿瘤的典型特征。这些数据表明，紫杉醇诱导的细胞质空泡死亡不是肿瘤。 Annexin V-FITC / PI细胞凋亡检测试剂盒进行的FCM分析进一步证明，紫杉醇诱导的细胞质空泡死亡并不凋亡。

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