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首页> 外文期刊>Journal of International Medical Research >Comparison of the Effects of Hypertonic Saline and Crystalloid Infusions on Haemodynamic Parameters during Haemorrhagic Shock in Dogs
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Comparison of the Effects of Hypertonic Saline and Crystalloid Infusions on Haemodynamic Parameters during Haemorrhagic Shock in Dogs

机译：高渗盐和晶体输注对犬出血性休克期间血流动力学参数影响的比较

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摘要

Haemorrhagic shock, a leading cause of mortality, frequently accompanies cardiac interventions. The administration of small volumes of hypertonic saline solutions and crystalloid solutions may reduce the severity and duration of shock, and result in a decrease in adverse outcomes. Under general anaesthesia, hypotension was induced in 12 healthy dogs. After 30 min, dogs received either hypertonic saline solution or lactated Ringer's solution for fluid resuscitation. In both groups, decreases in haemodynamic variables were observed during the shock period. Following resuscitation, increases in haemodynamic variables were observed. This increase lasted longer in dogs receiving hypertonic saline. In both groups, haematocrit and oxygen content values decreased after resuscitation and lactate levels increased. During resuscitation, lactate levels decreased. Sodium and osmolarity increased with resuscitation, then subsequently decreased. In conclusion, in a model of haemorrhagic shock, the administration of hypertonic saline solutions provides haemodynamic stability and tissue oxygenation more rapidly.
机译：出血性休克是导致死亡的主要原因，经常伴随心脏干预。少量高渗盐溶液和晶体溶液的给药可以降低休克的严重程度和持续时间，并减少不良后果。在全身麻醉下，在12只健康犬中诱发了低血压。 30分钟后，犬接受高渗盐溶液或乳酸林格氏液进行液体复苏。两组均在休克期血流动力学变量降低。复苏后，观察到血液动力学变量增加。这种增加在接受高渗盐水的狗中持续更长的时间。在两组中，复苏后血细胞比容和氧含量降低，乳酸水平升高。复苏期间，乳酸水平降低。钠和渗透压随复苏而增加，然后下降。总之，在失血性休克模型中，高渗盐溶液的给药可以更快地提供血流动力学稳定性和组织氧合。

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