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首页> 外文期刊>Journal of International Medical Research >TP53 Codon 72 Polymorphism with Hepatocellular Carcinoma: A Meta-Analysis
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TP53 Codon 72 Polymorphism with Hepatocellular Carcinoma: A Meta-Analysis

机译：TP53密码子72多态性与肝细胞癌：荟萃分析

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OBJECTIVE: The association between codon 72 polymorphism of the tumour protein p53 (TP53) gene — which results in a mis-sense mutation of arginine (R) to proline (P) – and susceptibility to hepatocellular carcinoma (HCC) is controversial. A meta-analysis was performed in order to define this relationship more precisely. METHODS: Published studies of TP53 codon 72 polymorphism and the risk of HCC were identified. Data were extracted, and summary odds ratios (OR) and 95% confidence intervals (95% CI) were calculated. Pooled ORs were determined for an additive model (R/R versus P/P), a dominant model ([R/R + R/P] versus P/P) and a recessive model (R/R versus [R/P + P/P]). RESULTS: The meta-analysis included seven case—control studies (total 1511 cases and 2165 controls). The risk of cancer was significantly decreased in the overall dominant model and the dominant model in Asian populations. A significantly decreased risk was found for all models in hospital-based but not population-based studies. There was no association between polymorphism and cancer risk when data were stratified according to hepatitis B or C virus infection status. CONCLUSION: The TP53 codon 72 polymorphism may be a risk factor for HCC.
机译：目的：肿瘤蛋白p53（TP53）基因的72位密码子多态性与精氨酸（R）突变为脯氨酸（P）的错义突变与肝细胞癌（HCC）的敏感性之间存在关联。进行荟萃分析以便更精确地定义这种关系。方法：确定已发表的TP53密码子72基因多态性和肝癌风险的研究。提取数据，并计算汇总比值比（OR）和95％置信区间（95％CI）。确定累加的OR，用于加性模型（R / R与P / P），优势模型（[R / R + R / P]与P / P）和隐性模型（R / R与[R / P + P / P]）。结果：荟萃分析包括七项病例对照研究（总共1511例病例和2165例对照）。在总体优势模型和亚洲人群的优势模型中，癌症风险显着降低。在基于医院的研究中而非基于人群的研究中，所有模型的风险均显着降低。根据乙型或丙型肝炎病毒感染状况对数据进行分层时，多态性与癌症风险之间没有关联。结论：TP53密码子72多态性可能是肝癌的危险因素。

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