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首页> 外文期刊>Journal of International Medical Research >A Double-Blind Study of Trazodone and Mianserin in the Treatment of Depression in General Practice
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A Double-Blind Study of Trazodone and Mianserin in the Treatment of Depression in General Practice

机译：曲唑酮和米安色林治疗抑郁症的双盲研究

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The antidepressant and anxiolytic efficacy of trazodone (100–200 mg daily), mianserin (60–120 mg daily) and diazepam (15–30 mg daily) was evaluated in ninety-three patients suffering from mild to moderate depression, with or without anxiety, over 6 weeks in a double-blind non-crossover general practice study. Efficacy was evaluated using the Hamilton Depression Rating Scale, Patient Self-Rating Visual Analogue scales, physician global assessments and the Zung Self-Rating Anxiety Scale. All three treatments significantly reduced symptoms of depression, as measured on the Hamilton Depression Rating Scale and the physician's assessment of Global Improvement. Trazodone was significantly superior to both mianserin and diazepam. As assessed using Visual Analogue Scales, trazodone was also shown to be significantly superior to diazepam in improving the patient's ability to concentrate and in reducing daytime tiredness. Although evidence of efficacy was found, there were no differences in activity between the treatment groups using the physician's assessment of Current Severity or on assessment of Therapeutic Effect. The treatments all caused a reduction in anxiety as assessed by the Zung Self-Rating Scale. The overall incidence of side-effects was similar between groups. For those side-effects considered to be significantly interfering with the patient's function, but not outweighing the therapeutic effect, a reduction of dosage was effective. Several patients complaining of drowsiness or lethargy as an unacceptable daytime side-effect were switched successfully from twice daily to night-time dosing. Significantly more patients with side-effects (outweighing therapeutic effect or in the presence of no improvement) were withdrawn from the mianserin group than from the trazodone or diazepam groups. Overall, the therapeutic efficacy in relation to the incidence of clinically significant side-effects, favoured trazodone for the treatment of general practice patients suffering from depression, with or without anxiety.
机译：在患有轻度至中度抑郁症，有或无焦虑症的93例患者中评估了曲唑酮（每日100-200 mg），米安色林（每日60-120 mg）和地西epa（每日15-30 mg）的抗抑郁和抗焦虑作用，在一项双盲非交叉通用实践研究中超过6周。使用汉密尔顿抑郁评估量表，患者自评视觉模拟量表，医师整体评估和Zung自评焦虑量表评估疗效。根据汉密尔顿抑郁评估量表和医生对整体改善的评估，这三种治疗均显着减轻了抑郁症状。曲唑酮显着优于米安色林和地西m。使用视觉模拟量表进行评估，在提高患者的专心能力和减少白天的疲倦方面，曲唑酮也被证明显着优于地西m。尽管发现了疗效的证据，但使用医生对当前严重程度的评估或对治疗效果的评估，治疗组之间的活动没有差异。根据Zung自评量表评估，所有治疗均导致焦虑减轻。两组之间副作用的总发生率相似。对于那些被认为会严重干扰患者功能，但不超过治疗效果的副作用，减少剂量是有效的。几名抱怨嗜睡或嗜睡是白天不可接受的副作用的患者已成功地从每天两次转为夜间用药。相较于曲唑酮或地西epa组，从米安色林组退出治疗的副作用大（超过治疗效果或无改善）的患者明显多。总的来说，与临床上显着的副作用的发生率有关的治疗功效，优选曲唑酮用于治疗患有或不患有焦虑症的抑郁症的普通患者。

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