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首页> 外文期刊>Journal of International Medical Research >Altered activation in visual cortex: Unusual functional magnetic resonance imaging finding in early Parkinson’s disease
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Altered activation in visual cortex: Unusual functional magnetic resonance imaging finding in early Parkinson’s disease

机译：视觉皮层的激活改变：早期帕金森氏病的异常功能磁共振成像发现

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Objective Movement dysfunction in Parkinson’s disease (PD) is well documented but its cause remains unclear. This study examined whether motor symptoms are caused by sensory impairment, executive dysfunction or other factors. Methods We examined the integration of tactile and motor programmes using functional magnetic resonance imaging (fMRI) in early stage PD patients compared with neurologically normal controls, to investigate neural mechanisms underlying movement dysfunction. Results Twenty-two control participants exhibited activation in an extensive network of cortical regions involved in tactile–motor integration. Decreased activation in somatosensory and motor regions during performance of passive tactile and movement tasks was found in 21 PD patients. The extrastriate visual cortex exhibited greater activation in controls during performance of the tasks. In contrast, greater activation in bilateral prefrontal regions was found in PD patients. Conclusions These results indicate that the extrastriate visual cortex is a multisensory region playing an important role in sensorimotor integration. The findings suggest that PD patients exhibit decreased activation in the extrastriate visual cortex, possibly related to dysfunctional integrative processing, and compensatory activity in the prefrontal cortex.
机译：帕金森氏病（PD）的客观运动功能障碍已有充分文献记载，但其原因尚不清楚。这项研究检查了运动症状是否是由感觉障碍，执行功能障碍或其他因素引起的。方法我们比较了早期PD患者与功能正常的神经系统对照者相比，使用功能性磁共振成像（fMRI）的触觉和运动程序的整合，以研究运动功能障碍的神经机制。结果22名对照参与者在涉及触觉-运动整合的广泛皮质区域网络中表现出激活作用。在21名PD患者中发现被动执行触觉和运动任务期间，体感和运动区域的激活减少。在执行任务的过程中，超细纹皮层在控件中表现出更大的激活性。相反，在PD患者中发现双侧前额叶区域的活化更大。结论这些结果表明，外视皮层是一个多感觉区，在感觉运动整合中起着重要作用。研究结果表明，PD患者在外视皮层中的激活减少，这可能与功能障碍的整合加工以及额叶前皮层的代偿活动有关。

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