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首页> 外文期刊>Journal of International Medical Research >Efficacy of Prophylactic Ondansetron in a Patient-Controlled Analgesia Environment
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Efficacy of Prophylactic Ondansetron in a Patient-Controlled Analgesia Environment

机译：病人自控镇痛环境中预防性恩丹西酮的疗效

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We conducted a prospective, randomized, double-blind, placebo-controlled trial to examine the efficacy of prophylactic ondansetron on post-operative nausea and vomiting (PONV) during opioid patient-controlled analgesia (PCA). In total, 374 patients using opioid PCA, but otherwise considered to be low risk for PONV, were randomly allocated to ondansetron (4 mg given intravenously and 16 mg added into the PCA pump) or saline (control group). PONV was evaluated in terms of nausea graded on a visual analogue scale, and the number of patients who experienced emetic episodes or needed rescue anti-emetics in the 48-h post-operative period. Patient satisfaction for PCA was scored at the end of the evaluation period. The only difference between the two groups was the higher number of headaches in the ondansetron group. In patients using opioid PCA, but with no other high risk factors for PONV, prophylactic ondansetron does not have any clinical benefit.
机译：我们进行了一项前瞻性，随机，双盲，安慰剂对照试验，以研究预防性恩丹西酮对阿片类药物患者自控镇痛（PCA）术后恶心和呕吐（PONV）的疗效。总共有374名使用阿片类PCA的患者被随机分配至昂丹司琼（静脉注射4 mg，PCA泵中添加16 mg）或生理盐水（对照组），但该患者另外被认为是PONV风险低。根据视觉模拟量表上的恶心等级对PONV进行评估，并在术后48小时内经历呕吐发作或需要抢救止吐药的患者人数。在评估期结束时对PCA的患者满意度进行评分。两组之间唯一的区别是恩丹西酮组头痛的发生率更高。在使用阿片类药物PCA但无其他PONV高危因素的患者中，预防性恩丹西酮没有任何临床益处。

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