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首页> 外文期刊>Journal of International Medical Research >A New Skeletal Muscle Relaxant (DS 103-282*) Compared to Diazepam in the Treatment of Muscle Spasm of Local Origin
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A New Skeletal Muscle Relaxant (DS 103-282*) Compared to Diazepam in the Treatment of Muscle Spasm of Local Origin

机译：与地西p相比，一种新型的骨骼肌松弛剂（DS 103-282 *）治疗局部性肌肉痉挛

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The myotonolytic activity of a new muscle-relaxant, DS 103-282, was compared with that of diazepam in a randomized double-blind study on thirty patients suffering from acute muscular spasm due to disorders of the cervical and lumbar segments of the spine. Fifteen patients received 4 mg DS 103-282 and fifteen received 5 mg diazepam on a three times daily regime for 7 days. DS 103-282 was found to alleviate symptoms and improve mobility to a significant degree (p ≥ 0.05) in all parameters evaluated and was also significantly superior to diazepam in 5 of these. Onset of action was particularly rapid for DS 103-282. Both medications were well tolerated and there was no significant difference between them. On the basis of these data DS 103-282 may be considered a more powerful and faster-acting myotonolytic agent than diazepam with which it was compared in similar clinical indications.
机译：在一项针对30名因脊椎颈段和腰段疾病而患有急性肌肉痉挛的患者的随机双盲研究中，将新型肌肉松弛剂DS 103-282与地西epa的肌溶解活性进行了比较。 15例患者接受3天内每日3次方案，分别接受4 mg DS 103-282和15 mg地西epa治疗，共7天。发现DS 103-282在所有评估的参数中均能缓解症状并显着改善运动性（p≥0.05），并且在其中5个参数中也显着优于地西epa。 DS 103-282的起效特别迅速。两种药物的耐受性良好，两者之间无显着差异。根据这些数据，DS 103-282被认为是比地西epa更有效和作用更快的肌溶酶，在类似的临床适应症中与之相比。

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