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首页> 外文期刊>Journal of King Saud University >Cytotoxic and apoptosis induction potential of Mimusops elengi L. in human cervical cancer (SiHa) cell line
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Cytotoxic and apoptosis induction potential of Mimusops elengi L. in human cervical cancer (SiHa) cell line

机译： lenomops elengi L。对人宫颈癌（SiHa）细胞系的细胞毒性和凋亡诱导潜力

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摘要

Bullet wood tree, also called Spanish cherry ( Mimusops elengi L.) is a medium-sized evergreen tree belonging to family Sapotaceae which is widely used in the treatment of different ailments. The present study investigated cytotoxic potential of methanolic leaf and bark extracts against human cervical cancer cell line (SiHa) by MTT (3-(4,5-dimethylthiazol-2-yl)-2; 5-diphenyltetrazolium bromide) assay, the apoptotic cells were quantified further by flow cytometry by FACS fluorescence activated cell sorting. The extract of M. elengi bark and leaf was effective towards tested cell line, with IC 50 values of 35.08 ± 2.92 μg/ml and 67.46 ± 4.21 μg/ml respectively. Further there is an increase in apoptotic bodies from 0.24% to 60% and 69% after treatment with extracts. These extracts exhibit significant cytotoxic effect by inducing apoptosis. The M. elengi has never shown anticancer activity on SiHa cells. These findings suggested that extracts and compounds from this plant could be useful for preventing and treating human gynaecologic cancer disease.
机译：子弹木树，也称为西班牙樱桃（Mimusops elengi L.）是属于Sapotaceae家族的中型常绿树，广泛用于治疗各种疾病。本研究通过MTT（3-（4,5-二甲基噻唑-2-基）-2; 5-二苯基四唑鎓溴化物）检测凋亡细胞来研究甲醇叶和树皮提取物对人宫颈癌细胞系（SiHa）的细胞毒性潜力。通过FACS荧光激活细胞分选通过流式细胞术进一步定量。 e叶树皮和叶提取物对受试细胞系有效，IC 50值分别为35.08±2.92μg/ ml和67.46±4.21μg/ ml。此外，用提取物处理后，凋亡小体从0.24％增加到60％和69％。这些提取物通过诱导凋亡表现出显着的细胞毒性作用。埃及支原体从未对SiHa细胞显示出抗癌活性。这些发现表明，该植物的提取物和化合物可用于预防和治疗人类妇科癌症疾病。

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