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首页> 外文期刊>Journal of International Medical Research >Effects of Ibudilast on Calcium Deposition in Soft Tissues of Rabbits with Atherosclerosis
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Effects of Ibudilast on Calcium Deposition in Soft Tissues of Rabbits with Atherosclerosis

机译：异丁司特对动脉粥样硬化兔软组织钙沉积的影响

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The effects of 2.5 mg/kg·day ibudilast, with or without 300 mg/kg·day nicomol, or 10 mg/kg·day ibudilast on calcium and magnesium concentrations in the central nervous system (CNS), heart, liver, kidney, skeletal muscle, abdominal aorta and bone were determined in rabbits fed a 1% cholesterol-rich diet for 3 months. Serum thromboxane B2 concentrations were reduced in rabbits treated with 10 mg/kg·day ibudilast or with 2.5 mg/kg·day ibudilast plus 300 mg/kg·day nicomol, and atherosclerotic lesions were ameliorated compared with untreated rabbits. Calcium concentrations in the frontal cortex and cerebellum were lower in ibudilasticomol-treated rabbits and in those fed a standard diet compared with those receiving a cholesterol-rich diet only. Calcium concentrations in the pons and abdominal aorta were also lower in ibudilasticomol-treated rabbits whereas the calcium concentrations in the cerebellum were lower in rabbits treated with either 2.5 or 20 mg/kg·day ibudilast. There were no significant changes in tissue magnesium concentrations after feeding a cholesterol-rich diet, with or without drug treatment. It is concluded that 2.5 mg/kg·day ibudilast plus 300 mg/kg·day nicomol or 10 mg/kg·day ibudilast produced a scavenger effect on calcium deposited in the CNS and abdominal aorta of rabbits fed a cholesterol-rich diet.
机译：2.5 mg / kg·天的ibudilast，有或没有300 mg / kg·天的尼古丁或10 mg / kg·天的ibudilast对中枢神经系统（CNS），心脏，肝脏，肾脏，在喂食1％高胆固醇饮食3个月的兔子中测定骨骼肌，腹主动脉和骨骼。与未治疗的兔子相比，用10 mg / kg·天的ibudilast或2.5 mg / kg·天的ibudilast + 300 mg / kg·天的尼古洛尔治疗的兔血清血栓素B2浓度降低，并且动脉粥样硬化病变得到改善。与仅接受高胆固醇饮食的兔子相比，接受异丁司特/尼可莫尔治疗的兔子以及饲喂标准饮食的兔子的额叶皮层和小脑中的钙浓度较低。异丁司特/尼莫酚治疗的兔子的脑桥和腹主动脉中的钙浓度也较低，而接受2.5或20 mg / kg·天异丁司特治疗的兔子的小脑中的钙浓度较低。饲喂富含胆固醇的饮食（有或没有药物治疗）后，组织镁浓度无明显变化。结论是2.5 mg / kg·天的ibudilast加300 mg / kg·天的尼可醇或10 mg / kg·天的ibudilast对饲喂高胆固醇饮食的兔子的中枢神经系统和腹主动脉中的钙沉积具有清除作用。

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