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首页> 外文期刊>Journal of International Medical Research >Effects of Nitrate and Prophylactic Aspirin on Upper Gastrointestinal Bleeding: A Retrospective Case–Control Study
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Effects of Nitrate and Prophylactic Aspirin on Upper Gastrointestinal Bleeding: A Retrospective Case–Control Study

机译：硝酸盐和预防性阿司匹林对上消化道出血的影响：一项回顾性病例对照研究

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Experimental studies suggest that nitric-oxide-releasing drugs reduce gastroduodenal damage induced by non-steroidal anti-inflammatory drugs, but it is not known whether these agents have this effect in humans. The aim of the present study was to evaluate the risk of upper gastrointestinal bleeding in patients who receive aspirin and nitrates for vascular occlusive diseases. This was a retrospective case–control study of 736 consecutive patients admitted with upper gastrointestinal bleeding, compared with 1472 age- and sex-matched hospital controls. Chronic low-dose aspirin regimens had been used by 12.6% of cases and 5.7% of controls, nitrates by 4.8% and 5.8%, and combined nitrates and low-dose aspirin by 2.7% and 1.9%, respectively. Logistic regression analysis identified low-dose aspirin use as an independent risk factor for gastrointestinal bleeding, whereas nitrate use was found to be a protective factor. The combination of both nitrate and low-dose aspirin was not associated with an increased risk of bleeding.
机译：实验研究表明，释放一氧化氮的药物可减少非甾体类抗炎药引起的胃十二指肠损伤，但尚不清楚这些药物是否对人体具有这种作用。本研究的目的是评估接受阿司匹林和硝酸盐治疗血管闭塞性疾病的患者上消化道出血的风险。这是一项回顾性病例对照研究，对736例上消化道出血的连续住院患者与1472例年龄和性别相匹配的医院对照进行了比较。慢性低剂量阿司匹林方案的使用率为12.6％，对照组为5.7％，硝酸盐为4.8％和5.8％，硝酸盐和低剂量阿司匹林的组合分别为2.7％和1.9％。 Logistic回归分析确定低剂量阿司匹林的使用是胃肠道出血的独立危险因素，而硝酸盐的使用是一种保护因素。硝酸盐和小剂量阿司匹林的组合与出血风险增加无关。

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