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首页> 外文期刊>Journal of International Medical Research >The Corticotrophin Releasing Factor Test: A Valuable and Rapid Procedure for the Differential Diagnosis of Hirsutism
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The Corticotrophin Releasing Factor Test: A Valuable and Rapid Procedure for the Differential Diagnosis of Hirsutism

机译：促肾上腺皮质激素释放因子测试：鉴别诊断多毛症的一种有价值的快速程序

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摘要

Plasma concentrations of adrenocorticotrophic hormone, Cortisol, 17-hydroxyprogesterone, testosterone, Δ4-androstenedione and dehydroepiandrosterone sulphate were determined in 10 regularly menstruating hirsute women 0, 15, 30, 60, 90 and 120 min after intravenous injection of 100 μg corticotrophin releasing factor. The baseline concentrations of adrenocorticotrophic hormone, Cortisol, progesterone and dehydroepiandrosterone sulphate were within the normal range, whereas the mean Δ4-androstenedione and testosterone concentrations were mildly elevated. The administration of corticotrophin releasing factor induced a rapid and significant increase in plasma concentrations of adrenocorticotrophic hormone, Cortisol, 17-hydroxyprogesterone and Δ4-androstenedione after 60 min, whereas dehydroepiandrosterone sulphate and testosterone concentrations were not significantly elevated. These findings suggest that the corticotrophin releasing factor test can readily be used as an out-patient procedure to exclude adrenal hirsutism.
机译：在静脉注射100μg促肾上腺皮质激素释放因子后，分别在10名经月经期多毛妇女0、15、30、60、90和120分钟内测定了肾上腺皮质营养激素，皮质醇，17-羟孕酮，睾丸激素，Δ4-雄烯二酮和硫酸脱氢表雄酮的血浆浓度。肾上腺皮质营养激素，皮质醇，孕酮和脱氢表雄酮硫酸盐的基线浓度在正常范围内，而平均Δ4-雄烯二酮和睾丸激素浓度则轻度升高。服用促肾上腺皮质激素释放因子后60分钟后，血浆中肾上腺皮质营养激素，皮质醇，17-羟基孕酮和Δ4-雄烯二酮的浓度迅速而显着增加，而硫酸脱氢表雄酮和睾丸激素的浓度并未显着升高。这些发现表明，促肾上腺皮质激素释放因子测试可以很容易地用作门诊程序，以排除肾上腺多毛症。

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