...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of International Medical Research >Gamma-glutamyl transpeptidase to platelet ratio index is a good noninvasive biomarker for predicting liver fibrosis in Chinese chronic hepatitis B patients
【24h】

Gamma-glutamyl transpeptidase to platelet ratio index is a good noninvasive biomarker for predicting liver fibrosis in Chinese chronic hepatitis B patients

机译：γ-谷氨酰转肽酶与血小板的比率指数是预测中国慢性乙型肝炎患者肝纤维化的良好非侵入性生物标志物

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Objective To evaluate whether gamma-glutamyl transpeptidase to platelet ratio index (GPRI) can diagnose the extent of liver fibrosis in Chinese patients with chronic hepatitis B (CHB) infection. Methods This prospective observational study used liver biopsy results as the gold standard to evaluate the ability of GPRI to predict hepatic fibrosis compared with two other markers, the aspartate aminotransferase (AST) to platelet ratio index (APRI) and fibrosis-4 score (FIB-4). The clinical and demographic factors that affected GPRI, independent of liver fibrosis, were assessed using multivariate linear regression analyses. Results This study enrolled 312 patients with CHB. GPRI had a significantly positive correlation with liver fibrosis stage and the correlation coefficient was higher than that for APRI and FIB-4. The areas under the receiver operating curves for GPRI for significant fibrosis, bridging fibrosis, and cirrhosis were 0.728, 0.836, and 0.842, respectively. Of the three indices, GPRI had the highest diagnostic accuracy for bridging fibrosis and cirrhosis. Age, elevated AST and elevated total bilirubin levels were independent determinants of increased GPRI. Conclusion GPRI was a more reliable laboratory marker than APRI and FIB-4 for predicting the stage of liver fibrosis in Chinese patients with CHB.
机译：目的探讨γ-谷氨酰转肽酶与血小板的比率指数（GPRI）是否可以诊断中国慢性乙型肝炎（CHB）患者的肝纤维化程度。方法这项前瞻性观察性研究以肝活检结果为金标准，以评估GPRI预测肝纤维化的能力，并与其他两个指标（天冬氨酸转氨酶（AST）与血小板比率指数（APRI）和4型纤维化评分（FIB- 4）。使用多元线性回归分析评估了影响GPRI的临床和人口统计学因素，独立于肝纤维化。结果本研究招募了312例CHB患者。 GPRI与肝纤维化分期呈显着正相关，相关系数高于APRI和FIB-4。对于严重纤维化，桥接纤维化和肝硬化，GPRI接收器工作曲线下的面积分别为0.728、0.836和0.842。在这三个指标中，GPRI对桥接纤维化和肝硬化的诊断准确性最高。年龄，AST升高和总胆红素水平升高是GPRI升高的独立决定因素。结论GPRI是预测中国CHB患者肝纤维化分期的可靠指标，优于APRI和FIB-4。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号