Synthesis, characterization and effect of bis-1,3,4-oxadiazole rings containing glycine moiety on the activity of some transferase enzymes

Ivan H.R. Tomi; Alaa H.J. Al-Qaisi; Zyad H.J. Al-Qaisi

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Synthesis, characterization and effect of bis-1,3,4-oxadiazole rings containing glycine moiety on the activity of some transferase enzymes

机译：含甘氨酸部分的bis-1,3,4-恶二唑环的合成，表征及对某些转移酶活性的影响

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We described herein the synthesis of bis-1,3,4-oxadiazole containing glycine moiety. N -{5-[5-(4-Methoxyphenyl)-1,3,4-oxadiazole-2-yl-sulfanyl]-1,3,4-oxadiazole-2-yl-methyl}-4-methoxybenzamide was fully characterized by elemental analysis, FT-IR and 1 H NMR spectroscopy. Also this study was designed to show the effects of bis-oxadiazole compound on the activities of some transferase enzymes such as: GOT, GPT and γ-GT in sera. This compound demonstrated activation on GOT and GPT activities, inhibitory effects on the γ-GT activity. These effects increased with increasing the concentration of the compound. The causes of the increases and decreases in the enzymes activities are discussed.

机译：我们在本文中描述了含有甘氨酸部分的双-1,3,4-恶二唑的合成。充分表征了N-{5- [5-（4-甲氧基苯基）-1,3,4-恶二唑-2-基-硫烷基] -1,3,4-恶二唑-2-基甲基} -4-甲氧基苯甲酰胺通过元素分析，FT-IR和1 H NMR光谱分析。本研究还旨在显示双恶二唑化合物对血清中某些转移酶如GOT，GPT和γ-GT的活性的影响。该化合物显示出对GOT和GPT活性的激活，对γ-GT活性的抑制作用。这些作用随着化合物浓度的增加而增加。讨论了酶活性增加和减少的原因。

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《Journal of King Saud University》 |2011年第1期|共11页
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Ivan H.R. Tomi; Alaa H.J. Al-Qaisi; Zyad H.J. Al-Qaisi;
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中图分类自然科学理论与方法论;
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机译：含甘氨酸部分的bis-1,3,4-恶二唑环的合成，表征及对某些转移酶活性的影响

Synthesis, characterization and effect of bis-1,3,4-oxadiazole rings containing glycine moiety on the activity of some transferase enzymes

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