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首页> 外文期刊>Journal of King Saud University >Effect of Caesalpinia bonducella seed extract on histoarchitecture of some vital organs and clinical chemistry in female albino rats
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Effect of Caesalpinia bonducella seed extract on histoarchitecture of some vital organs and clinical chemistry in female albino rats

机译:es藜种子提取物对雌性白化病大鼠某些重要器官的组织结构和临床化学的影响

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The effect of an ethanolic seed extract of Caesalpinia bonducella F., (Caesalpiniaceae) on the histoarchitecture of the some vital organs and clinical chemistry was evaluated in Wistar female albino rats. The study was divided into four groups. Group I received distilled water and served as vehicle treated control. Groups II, III and IV were orally administered 100, 200 and 300?mg/kg b.wt dose of seed extract respectively for 10 consecutive days and subsequently euthanized twenty four hours after the last dose. Histoarchitecture of the vital tissues in treated groups appeared normal. Hematological analysis showed a significant increase in RBC count, various types of WBCs, platelet count, hemoglobin levels and packed cell volume levels in all the seed extract treated groups. Serum biochemistry revealed significantly decreased cholesterol, triglycerides and creatinine levels whereas HDL level was found to be significantly increased in all the treated groups. Our results suggest that the ethanolic seed extract of C. bonducella probably possesses chemical constituents of cytoprotective potential and should be further explored as a source of natural medicine.
机译:在Wistar雌性白化病大鼠中评估了Caesalpinia bonducella F.(Caesalpiniaceae)的乙醇种子提取物对某些重要器官的组织结构和临床化学的影响。该研究分为四组。第一组接受蒸馏水作为媒介物处理的对照组。 II,III和IV组分别连续10天口服100、200和300μmg/ kg b.wt剂量的种子提取物,随后在最后一剂后24小时实施安乐死。治疗组中重要组织的组织结构似乎正常。血液学分析显示,在所有种子提取物处理组中,RBC计数,各种类型的WBC,血小板计数,血红蛋白水平和堆积细胞体积水平显着增加。血清生化显示胆固醇,甘油三酸酯和肌酐水平显着降低,而所有治疗组的HDL水平均显着升高。我们的结果表明,黏结梭菌的乙醇种子提取物可能具有细胞保护作用的化学成分,应进一步探索作为天然药物的来源。

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