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首页> 外文期刊>Journal of Kermanshah University of Medical Sciences >The comparison of findings obtained by brain magnetic resonance imaging in schizophrenic and non-schizophrenic patients
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The comparison of findings obtained by brain magnetic resonance imaging in schizophrenic and non-schizophrenic patients

机译：精神分裂症和非精神分裂症患者的脑磁共振成像结果比较

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Background: With regard to the high prevalence of schizophrenia, research on brain structural changes in this disease has been one of the interesting issues among the medical scientists. In this research, brain MRI findings of schizophrenic patients have been compared with non-schizophrenic ones. Methods: This study was an analytic-comparative one in which two groups of schizophrenic and non-schizophrenic patients were compared with regards to variables in brain MRI such as mean volume of lateral ventricles, and cerebrospinal fluid (qualitative variables), temporal lobes, thalami, hippocampi and unci(quantitative variables). For qualitative variables analysis Chi-square test has been used and for quantitative ones applied independent T-test was employed. In this study following equalization of age and sex 22 schizophrenic patients were compared with 54 non-schizophrenic ones. Results: Statistical analysis demonstrated that the changes were independent from age and sex and followed natural and equal distribution pattern. Lateral ventricles volume had no statistically meaningful changes (p>0.05). Cerebrospinal fluid volume in schizophrenic group increased considerably comparing to non-schizophrenic ones (p<0.001) while mean volume of bilateral temporal lobes decreased from 219000 in control group to 160000 cubic millimeter in case group, for thalami from 24000 to 15900, for hippocampi from 8586 to 3513 and for unci from 27900 to 16000 respectively (p<0.001). Conclusion: This study demonstrates that particular structural changes are seen in schizophrenic patients’ brain (such as increase in cerebrospinal fluid volume and decrease in temporal, thalami, hippocampi and unci volume) and MRI is a suitable modality to show these changes.
机译：背景：关于精神分裂症的高患病率，对这种疾病的大脑结构变化的研究一直是医学科学家感兴趣的问题之一。在这项研究中，将精神分裂症患者的脑部MRI结果与非精神分裂症患者的脑MRI结果进行了比较。方法：这项研究是一项分析比较研究，其中比较了两组精神分裂症患者和非精神分裂症患者的脑部MRI变量，例如侧脑室的平均体积和脑脊液（定性变量），颞叶，丘脑，海马和unci（定量变量）。对于定性变量分析，使用卡方检验;对于定量变量，采用独立的T检验。在这项研究中，在年龄和性别均等之后，将22位精神分裂症患者与54位非精神分裂症患者进行了比较。结果：统计分析表明，这些变化与年龄和性别无关，并且遵循自然和均等的分布模式。侧脑室容积无统计学意义的变化（p> 0.05）。与非精神分裂症组相比，精神分裂症组的脑脊液量显着增加（p <0.001），而双侧颞叶的平均体积从对照组的219000下降至病例组的160000立方毫米，其中，丘脑的从24000下降到15900，海马的从8586至3513和unci从27900至16000（p <0.001）。结论：这项研究表明，在精神分裂症患者的大脑中可见特定的结构变化（例如脑脊液量增加，颞，丘脑，海马和unici量减少），而MRI是显示这些变化的合适方式。

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