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首页> 外文期刊>Journal of International Medical Research >Effects of different anaesthetics on cytokine levels in children with community-acquired pneumonia undergoing flexible fibreoptic bronchoscopy
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Effects of different anaesthetics on cytokine levels in children with community-acquired pneumonia undergoing flexible fibreoptic bronchoscopy

机译：不同麻醉药对柔性纤维支气管镜检查对社区获得性肺炎患儿细胞因子水平的影响

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Objective To determine the effects of propofol and sevoflurane on cytokine levels in children with community-acquired pneumonia undergoing flexible fibreoptic bronchoscopy (FFB). Method Children with community-acquired pneumonia were randomly assigned to receive 3–5?mg/kg propofol i.v. or 8% inhaled sevoflurane. Haemodynamic variables, stress hormone responses and serum cytokines were compared between the two groups. Results Out of 50 children aged 2–12 years (propofol, n ?=?25; sevoflurane, n ?=?25), there were no significant between-group differences in haemodynamic variables and stress hormones. Interleukin (IL)-6 and IL-10 decreased significantly following FFB in both groups. IL-6 levels were significantly lower in the sevoflurane group than propofol group at 4?h and 1?d following FFB (61.3?±?11.9 versus 82.6?±?19.7?pg/ml; 52.8?±?9.7 versus 75.4?±?13.6?pg/ml, respectively). IL-10 levels in the sevoflurane group were significantly lower than in the propofol group at 1?d following FFB. Conclusions In children with community-acquired pneumonia, use of sevoflurane was associated with lower circulating IL-6 and IL-10 levels compared with propofol, following FFB. Pneumonia severity is reflected by higher blood cytokine levels, thus, sevoflurane may be more beneficial to recovery from community-acquired pneumonia than propofol, however further studies are required to test this hypothesis.
机译：目的探讨丙泊酚和七氟醚对软性纤维支气管镜检查（FFB）的社区获得性肺炎患儿细胞因子水平的影响。方法将社区获得性肺炎患儿随机分配接受3–5？mg / kg异丙酚静脉注射。或8％吸入七氟醚。比较两组的血流动力学变量，应激激素反应和血清细胞因子。结果在50名2至12岁的儿童中（丙泊酚，n == 25;七氟醚，n == 25），血流动力学变量和应激激素组间无显着差异。两组FFB后白细胞介素（IL）-6和IL-10显着降低。七氟醚组在FFB后4h和1d时IL-6水平显着低于丙泊酚组（61.3±±11.9 vs 82.6±±19.7pg / ml; 52.8±±9.7 vs 75.4±±分别为13.6pg / ml。在FFB后1 d，七氟醚组的IL-10水平显着低于丙泊酚组。结论在FFB后，社区获得性肺炎患儿使用七氟醚与丙泊酚相比，循环IL-6和IL-10水平较低。较高的血液细胞因子水平反映了肺炎的严重性，因此七氟醚比丙泊酚更可能有助于从社区获得性肺炎的康复，但是需要进一步的研究来检验这一假说。

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