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首页> 外文期刊>Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society >Dendritic cells interact with CD4 T cells in intestinal mucosa
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Dendritic cells interact with CD4 T cells in intestinal mucosa

机译：树突状细胞与肠粘膜中的CD4 T细胞相互作用

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Absence of lymph nodes in nonmammalian species, expression of MHCII by APCs in the periphery, and the recent findings that T cells can change their polarization status after presentation in the lymph nodes imply a role for MHCII-mediated presentation outside the organized lymphoid tissue. This study shows that MHCII+ ECs and DCs from the intestinal mucosa of the pig can present antigen to T cells in vitro. In vivo, APCs colocalize with T cells in pig and mouse intestinal mucosa. In the pig, endothelium is involved in these interactions in neonates but not in adults, indicating different roles for stromal and professional APCs in the neonate compared with the adult. The ratio of expression of DQ and DR MHCII locus products was lower on ECs than on other mucosal APCs, indicating that the two types of cells present different peptide sets. Adult nonendothelial APCs expressed a higher ratio of DQ/DR than in neonates. These results suggest that mucosal DCs can present antigen locally to primed T cells and that stromal APCs are recruited to these interactions in some cases. This raises the possibility that local presentation may influence T cell responses at the effector stage after initial presentation in the lymph node.
机译：非哺乳动物物种中不存在淋巴结，外周APC表达MHCII，以及最近发现T细胞在淋巴结中呈递后可改变其极化状态的最新发现暗示着MHCII介导的有组织淋巴组织外呈递的作用。这项研究表明，猪肠道粘膜中的MHCII + EC和DC可以在体外将抗原呈递给T细胞。在体内，APC与猪和小鼠肠粘膜中的T细胞共定位。在猪中，内皮在新生儿中参与这些相互作用，但在成年动物中不参与，这表明与成年动物相比，新生儿基质和专业APC的作用不同。在EC上，DQ和DR MHCII基因座产物的表达比率低于在其他粘膜APC上的表达比率，表明这两种类型的细胞具有不同的肽组。成人非内皮APC的DQ / DR比率高于新生儿。这些结果表明，粘膜DC可以将抗原局部地呈递给初免的T细胞，并且在某些情况下，基质APC被募集到这些相互作用中。这增加了在淋巴结中初次出现后，局部表现可能会在效应子阶段影响T细胞反应的可能性。

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