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首页> 外文期刊>Journal of medical bacteriology. >Investigated of ampC in Carbapenem Resistant Gram-Negative Bacteria Isolated from Burned Patients
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Investigated of ampC in Carbapenem Resistant Gram-Negative Bacteria Isolated from Burned Patients

机译：从烧伤患者中分离出耐碳青霉烯类革兰氏阴性细菌中的ampC的研究

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Background: Gram-Negative bacteria are the most cause of nosocomial infection especially in burned patients. Carbapenem resistant strains can limit seriously the choice of antibiotic therapy. AmpC can make resistance to carbapenem and detection of that can be useful for identification ofcarbapenem resistant. The aim of this study was identification of ampC in most prevalent cause of nosocomial infection.Methods: boronic acid combined with meropenem in combination disc method was used for phenotypic method and PCR was used for molecular identification of ampC.Results: Fifty one strains showed positive results in phenotypic method but 119 strains were harbored ampC gene. Combination disc method with meropenem and boronic acid showed 34.4% sensitivity and 78.5% specificity according to the results of this study.Conclusions: the results of this study were indicated the more prevalent of ampC in carbapenem resistant Gram-Negative bacteria. On the other hand use of boronic acid combined with meropenem showed low sensitivity for detection of ampC.
机译：背景：革兰氏阴性菌是医院感染的最主要原因，尤其是在烧伤患者中。对碳青霉烯类耐药的菌株会严重限制抗生素治疗的选择。 AmpC可产生对碳青霉烯的抗性，对其进行检测可用于鉴定对卡巴培南的抗性。方法：采用硼酸联合美罗培南联合圆盘法进行表型分析，采用PCR技术对ampC进行分子鉴定。结果：五十一株阳性。结果采用表型方法，但有119个菌株带有ampC基因。本研究结果表明，美罗培南与硼酸联合圆盘法的敏感性为34.4％，特异性为78.5％。结论：这项研究的结果表明，ampC在耐碳青霉烯的革兰氏阴性细菌中更为普遍。另一方面，结合使用硼酸和美罗培南显示出对ampC检测的低灵敏度。

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