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首页> 外文期刊>Journal of Medical Sciences >Implications of Nitric Oxide and Carbon Monoxide in Neonatal Sepsis
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Implications of Nitric Oxide and Carbon Monoxide in Neonatal Sepsis

机译：一氧化氮和一氧化碳在新生儿败血症中的意义

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Nitric oxide (NO) and carbon monoxide (CO) are proposed to regulate physiologic vascular tone, blood pressure , and tissue perfusion. To investigate their role in the pathogenesis of neonatal sepsis, plasma levels of NO and CO in 45 neonates with clinical evidence of sepsis plus positive blood culture as well as in 20 healthy neonates were assessed. Significantly higher plasma levels of NO and CO in sepsis group compared with control group were found (56.4 ± 21.1 vs. 33.4 ± 12.1 Fmol L-1, p -1, p < 0.0001, respectively). This increase in NO and CO levels occurred independent of gestational age, onset of sepsis, and gram stain of the isolated organism. Moreover, there were significantly higher plasma levels of NO and CO in septic infants who required inotropic support compared with those who did not require this support (p<0.0001). Plasma CO was higher in non-survivors compared with survivors (p=0.003). Significantly positive correlation between plasma NO and CO was observed. In conclusion, plasma NO and CO was increased in neonatal sepsis. This increase is independent of gestational age, onset of sepsis and gram stain of the isolated organism. Assay of plasma CO and NO may help to assess the severity of sepsis and progression to septic shock. The role of nitric oxide synthase (NOS) and heme oxygenase (HO) inhibitors in the management of neonatal sepsis should be investigated in further trials.
机译：一氧化氮（NO）和一氧化碳（CO）被提议来调节生理性血管紧张度，血压和组织灌注。为了调查其在新生儿败血症发病机理中的作用，对45名具有败血症加血培养阳性临床证据的新生儿以及20名健康新生儿的血浆NO和CO水平进行了评估。脓毒症组血浆NO和CO的水平明显高于对照组（56.4±21.1 vs. 33.4±12.1 Fmol L -1 ，p -1 ，p <0.0001，分别）。一氧化氮和一氧化碳水平的升高与胎龄，败血症的发作以及分离出的生物的革兰氏染色无关。而且，需要肌力支持的脓毒症婴儿的血浆NO和CO含量明显高于不需要这种药物的脓毒症婴儿（p <0.0001）。非幸存者的血浆CO高于幸存者（p = 0.003）。观察到血浆NO和CO之间显着正相关。总之，新生儿败血症的血浆NO和CO升高。这种增加与胎龄，败血症的发作和所分离生物的革兰氏染色无关。血浆一氧化碳和一氧化氮的含量可能有助于评估脓毒症的严重程度以及感染性休克的进展。一氧化氮合酶（NOS）和血红素加氧酶（HO）抑制剂在新生儿败血症管理中的作用应在进一步试验中进行研究。

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