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首页> 外文期刊>Journal of Medical Sciences >Safety of Garlic ( Allium Sativum ) and Turmeric ( Curcuma domestica ) Extract in Comparison with Simvastatin on Improving Lipid Profile in Dyslipidemia Patients
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Safety of Garlic ( Allium Sativum ) and Turmeric ( Curcuma domestica ) Extract in Comparison with Simvastatin on Improving Lipid Profile in Dyslipidemia Patients

机译：大蒜（大蒜）和姜黄（姜黄）提取物与辛伐他汀的比较对改善血脂异常患者血脂的安全性。

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Dyslipidemia is the major cause of atherosclerosis. A number of drugs that inhibit cholesterol synthesis has indicated to control lipid profile . However, these lipid lowering drugs are not free of side effect. Therefore a substance that less toxic and yet effective would be beneficial. Here we compared the anticholesterol effect of combination of garlic and turmeric extract, a herbal product, with a standard lipid lowering drug, simvastatin. Thirty nine people were recruited and randomized into two groups, Garlic-Turmeric (G-T) group (n = 19) received three times two capsules of garlic-turmeric extract (2.4 g day-1) and simvastatin group (n = 20) received placebo and 5 mg simvastatin to blind the subjects from knowing what drugs they get, for 14 weeks. Garlic-turmeric extract could improve lipid profile comparable with simvastatin (p = 0.366). There were no adverse event related to garlic-turmeric administration, even there was improvement in liver function at the end of the study. In conclusion garlic-turmeric extract could improve lipid profile comparable to simvastatin with no significant adverse event.
机译：血脂异常是动脉粥样硬化的主要原因。许多抑制胆固醇合成的药物已表明可以控制脂质分布。但是，这些降脂药物并非没有副作用。因此，毒性较小但有效的物质将是有益的。在这里，我们比较了大蒜和姜黄提取物（一种草药产品）与标准降脂药物辛伐他汀的组合的抗胆固醇作用。招募39人，随机分为两组，大蒜-姜黄（GT）组（n = 19）接受三次两粒大蒜-姜黄提取物胶囊（2.4 g day -1 ）和辛伐他汀组（n = 20）接受安慰剂和5毫克辛伐他汀以使受试者在14周内不知道自己会得到什么药物。大蒜-姜黄提取物可以改善脂质谱，与辛伐他汀相当（p = 0.366）。在研究结束时，没有发生与大蒜姜黄有关的不良事件，甚至肝功能也有所改善。总之，大蒜-姜黄提取物可改善血脂，与辛伐他汀相当，无明显不良事件。

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