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Examining Potential Risk Factors to Acute Pancreatitis Disease: A Comparison of Loglinear Models in a Malaysian Case Study

机译:检查急性胰腺炎疾病的潜在危险因素:在马来西亚案例研究中对数线性模型的比较

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Acute pancreatitis is not a new disease in Malaysia and the occurrence of the disease has increased from year to year. Death from the infection of acute pancreatitis is also on the rise. This is worrying situation for all Malaysians and medical institution. Therefore, this study aims to identify the strength and significant predisposing factors to acute pancreatitis based on the most suitable and parsimonious model. This study used patient?s data records between 2005 and February 2012 obtained from Universiti Kebangsaan Malaysia Medical Centre (UKMMC). The Chi-Square test and Mantel-Haenszel test of homogeneity was used to determine the association among potential risk factors to acute pancreatitis and the confounding variables in this study, respectively. Loglinear modeling methods was performed to find the most suitable and parsimonious model. Parameter estimates and odds ratios were used in testing the effect of risk factors in acute pancreatitis. Results show that alcohol, diabetes, gallstone and smoking are significantly associated with acute pancreatitis. In the loglinear analysis, it was found that homogeneous model is the most parsimonious model in explaining the potential risk factors to acute pancreatitis. Findings from test of effect sizes indicate that age and race are significantly associated between potential risk factor (diabetes, gallstone and smoking) and acute pancreatitis.
机译:在马来西亚,急性胰腺炎不是一种新疾病,而且这种疾病的发生率逐年增加。由急性胰腺炎感染引起的死亡也在增加。这对于所有马来西亚人和医疗机构来说都是令人担忧的情况。因此,本研究旨在根据最合适,最简约的模型确定急性胰腺炎的强度和重要诱因。这项研究使用了从2005年至2012年2月间从马来西亚大学医疗中心(UKMMC)获得的患者数据记录。采用卡方检验和Mantel-Haenszel检验的均一性分别确定了急性胰腺炎的潜在危险因素与混杂变量之间的关联。执行对数线性建模方法以找到最合适和最简约的模型。参数估计和比值比用于测试急性胰腺炎中危险因素的影响。结果显示,酒精,糖尿病,胆结石和吸烟与急性胰腺炎显着相关。在对数线性分析中,发现同质模型是解释急性胰腺炎潜在危险因素的最简化模型。效应量测试的结果表明,年龄和种族与潜在危险因素(糖尿病,胆结石和吸烟)和急性胰腺炎之间存在显着相关性。

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