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首页> 外文期刊>Journal of Medical Case Reports >Treatment of post-anesthesia dementia with perispinal etanercept injection and hyperbaric oxygen therapy: a case report
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Treatment of post-anesthesia dementia with perispinal etanercept injection and hyperbaric oxygen therapy: a case report

机译：脊髓周围注射依那西普和高压氧治疗麻醉后痴呆：一例

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BackgroundWe report on the first case of successful treatment for post-anesthesia dementia with perispinal etanercept injection combined with hyperbaric oxygen therapy. Case presentationOur patient was a 77-year-old Caucasian man of Mexican ethnicity who presented to our clinic 4.5?years after a knee replacement surgery. Immediately post-surgery, the patient began to show dramatic cognitive, physical, and emotional impairment compared with his presurgical state; these symptoms were still present when he arrived at our clinic. A clinical assessment and brain single-photon emission computer tomography were performed. Diagnoses of dementia with major cognitive deficits and aphasia were established. A 40-session course of hyperbaric oxygen therapy was initiated to address our patient’s impairments. After the first ten hyperbaric oxygen therapy treatments, our patient was administered 25?mg perispinal etanercept injections approximately once weekly for 5?months. Starting after the first perispinal etanercept injection, our patient began showing progressive improvements. By the 5-month follow-up, his cognitive and physical function were substantially restored. A follow-up single-photon emission computer tomography scan showed increased perfusion in several small, localized areas. ConclusionsIn this case of dementia and major cognitive disorder post major surgery and anesthesia, the very beneficial effect of combining hyperbaric oxygen therapy with perispinal etanercept is outlined.
机译：背景我们报道了首例成功的麻醉后痴呆症的治疗方法：脊柱周围注射依那西普联合高压氧治疗。病例介绍我们的患者是一名77岁的墨西哥裔白人，在膝关节置换手术4.5年后到我们诊所就诊。与手术前相比，患者在手术后立即开始表现出明显的认知，身体和情绪障碍。当他到达我们诊所时，这些症状仍然存在。进行了临床评估和脑单光子发射计算机断层扫描。建立了具有主要认知缺陷和失语症的痴呆症的诊断。开始进行40疗程的高压氧治疗，以解决我们患者的损伤。在前十次高压氧治疗之后，我们的患者大约每周一次接受25mg脊髓周围注射依那西普治疗，持续5个月。从第一次脊髓周围注射依那西普开始，我们的患者开始表现出逐步改善。经过5个月的随访，他的认知和身体机能基本恢复。后续的单光子发射计算机断层扫描显示在几个小的局部区域的灌注增加。结论在这种情况下，在大手术和麻醉后发生痴呆和重大认知障碍的情况下，概述了高压氧疗法与脊柱周围依那西普联合治疗的有益效果。

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