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首页> 外文期刊>Journal of medical bacteriology. >Encapsulation of Platelet in Kefiran Polymer and Detection of Bioavailability of Immobilized Platelet in Probiotic Kefiran as a New Drug for Surface Bleeding
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Encapsulation of Platelet in Kefiran Polymer and Detection of Bioavailability of Immobilized Platelet in Probiotic Kefiran as a New Drug for Surface Bleeding

机译：血小板在Kefiran聚合物中的包封和益生菌Kefiran中作为表面出血新药的固定化血小板的生物利用度检测

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Background: Kefir contains lactic acid bacteria (Lactobacillus, Lactococcus, Leuconostoc, Acetobacter and Streptococcus) and yeasts (Kluyveromyces, Torula, Candida, and Saccharomyces). Kefiran is the polysaccharide produced by lactic acid bacteria in kefir.?Methods: Kefiran was prepared from milk containing 0.5% fat and 10 grams kefir grains and was separated from kefir by ethanol (0.02 gram) following entrapping the platelets to this polymer. Ligand of the platelet-polysaccharide was studied by FTIR.?Results: FTIR results showed that the bands of C-O and C-O-C connections were formed and the polysaccharides had been attached to the receptors of the platelet glycoproteins (GP Ib, GPIIb / IIIa). Stability and encapsulation of the platelet and kefiran were assessed by Coulter Counter. Encapsulation of the platelets by polysaccharide at the beginning caused to reduce the number of platelets following by releasing of 50% of the platelets after 3 hours.?Conclusion: The platelets were encapsulated in kefiran polymer and detected for bioavailability as new drug for surface bleeding. Also, kefiran has antimicrobial and antifungal properties. On the other hand, the existence of nisin in kefiran could be useful as an antibacterial lantibiotic.
机译：背景：开菲尔含有乳酸菌（乳酸菌，乳球菌，亮葡菌，醋杆菌和链球菌）和酵母菌（克鲁维酵母，托鲁拉，念珠菌和酿酒酵母）。方法：开菲兰是由含有0.5％脂肪和10克开菲尔谷物的牛奶制得的开菲兰，并在将血小板包埋到该聚合物中后用乙醇（0.02克）与开菲尔分离。结果：FTIR结果表明形成了C-O和C-O-C连接带，并且多糖已经附着在血小板糖蛋白（GP Ib，GPIIb / IIIa）的受体上。通过Coulter Counter评估血小板和kefiran的稳定性和包封。开始时用多糖包封血小板会减少血小板的数量，随后在3小时后释放50％的血小板。结论：将血小板包封在kefiran聚合物中，并检测其生物利用度作为表面出血的新药。此外，kefiran具有抗菌和抗真菌特性。另一方面，在kefiran中存在乳链菌肽可以用作抗菌羊毛硫抗生素。

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