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首页> 外文期刊>Journal of Microbiology, Biotechnology and Food Sciences >A POSITIVE DOSE-RESPONSE OF QUERCETIN ON COMPACT BONE MICROSTRUCTURE OF MALE RABBITS
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A POSITIVE DOSE-RESPONSE OF QUERCETIN ON COMPACT BONE MICROSTRUCTURE OF MALE RABBITS

机译：槲皮素对雄性兔紧凑骨微结构的正剂量反应

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Quercetin is one of the most widely distributed flavonoids in plants which should have a broad range of significant health promoting properties. Its effect on bone microstructure of males has not been sufficiently investigated. Therefore, our study was aimed to determine the impact of quercetin on femoral bone microstructure in 5-month-old male rabbits. Nine rabbits were intramuscularly injected with following doses of quercetin: 10 μg/kg body weight (bw) (E1 group; n=3), 100 μg/kg bw (E2 group; n=3) and 1000 μg/kg bw (E3 group; n=3) for 90 days, 3 times per week. Three rabbits without quercetin administration served as a control group. An accelerated bone resorption at the endosteal surface and intensive periosteal bone apposition were observed in all rabbits administered quercetin. However, the most evident changes such as a thicker layer of primary vascular longitudinal bone tissue under periosteum and a lower density of secondary osteons were identified in males from the E3 group. Morphometrical evaluations of the compact bone showed significantly decreased sizes of primary osteons’ vascular canals and secondary osteons in rabbits exposed to the highest dose of quercetin. Sizes of secondary osteons were also lower in males from the E2 group. Our results demonstrate that quercetin has a positive dose-response on compact bone microstructure in male rabbits.
机译：槲皮素是植物中分布最广泛的类黄酮之一，应具有广泛的显着健康促进特性。它对男性骨微结构的影响尚未得到充分研究。因此，我们的研究旨在确定槲皮素对5月龄雄性兔股骨骨微结构的影响。九只兔子肌肉注射下列槲皮素剂量：10μg/ kg体重（bw）（E1组; n = 3），100μg/ kg bw（E2组; n = 3）和1000μg/ kg bw（E3组; n = 3），连续90天，每周3次。将三只未施用槲皮素的兔子作为对照组。在所有服用槲皮素的兔子中，观察到骨内膜表面的骨吸收加速和骨膜周围强烈的并置。然而，在E3组的男性中，发现了最明显的变化，例如骨膜下的主要血管纵向骨组织的较厚层和次骨的密度较低。紧密骨的形态计量学评估显示，暴露于最大剂量槲皮素的兔子中，原骨骨的血管和继发骨的大小明显减少。 E2组男性中次生骨的大小也较低。我们的研究结果表明槲皮素对雄性兔的紧凑型骨微结构具有积极的剂量反应。

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