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首页> 外文期刊>Journal of Ayub Medical College >EFFECT OF STANDARD INTERFERON AND RIBAVIRIN ON HAEMOGLOBIN LEVEL IN HEPATITIS-C PATIENTS
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EFFECT OF STANDARD INTERFERON AND RIBAVIRIN ON HAEMOGLOBIN LEVEL IN HEPATITIS-C PATIENTS

机译：标准干扰素和利巴韦林对丙型肝炎患者血红蛋白水平的影响

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Background: The standard treatment for HCV infection involves combination therapy with pegylated interferon and ribavirin. The study was conducted to determine the effect of standard interferon and ribavirin on the haemoglobin level in patients treated for hepatitis-C. Methods: PCR confirmed 58 patients of chronic hepatitis-C treated with standard interferon and ribavirin for six months were included in this case series study. The patients were followed up monthly. Haemoglobin was measured by Sysmex Haematology analyser at monthly interval to study change in its level. Result: The study found decrease in the mean haemoglobin levels during the six months treatment. when the mean of baseline haemoglobin was compared with the mean haemoglobin of six months treatment, a decrease of 2.05 gm/dl was observed and the result was statistically significant ( p= 0.000). Conclusion: Six months treatment of chronic hepatitis-C with standard interferon and ribavirin decreases haemoglobin to a significant level causing anaemia in susceptible patients. Keywords: interferon, ribavirin, haemoglobin, hepatitis-C
机译：背景：HCV感染的标准治疗方法包括聚乙二醇化干扰素和利巴韦林的联合治疗。进行该研究以确定标准干扰素和利巴韦林对丙型肝炎患者血红蛋白水平的影响。方法：PCR证实58例慢性丙型肝炎患者接受标准干扰素和利巴韦林治疗六个月，纳入该病例系列研究。对患者每月进行随访。每月通过Sysmex血液分析仪测量血红蛋白，以研究其水平的变化。结果：研究发现六个月的治疗期间平均血红蛋白水平降低。当将基线血红蛋白的平均值与六个月治疗的平均血红蛋白进行比较时，观察到下降了2.05 gm / dl，结果具有统计学意义（p = 0.000）。结论：用标准干扰素和利巴韦林治疗慢性丙型肝炎六个月，可将血红蛋白降低到显着水平，从而导致易感患者贫血。关键词：干扰素，利巴韦林，血红蛋白，丙型肝炎

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