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首页> 外文期刊>Journal of Molecular Genetics >Low Prevalence of Non-Subtype B HIV-1 Strains in the Texas Prisoner Population
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Low Prevalence of Non-Subtype B HIV-1 Strains in the Texas Prisoner Population

机译：德州囚犯人群中非亚型B型HIV-1菌株的患病率较低

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Genotypic drug resistance testing is standard of care in HIV management. The ViroSeq HIV-1 Genotyping System is commonly used in detecting HIV genomic mutations that confer resistance to specific types of antiretroviral drugs as an aid in treating HIV infection. Of note, the assay is FDA approved to detect only HIV-1 Group M Subtype B viral resistance. Subtype B was the most prevalent strain in developed counties when the assay was introduced into clinical care approximately 10 years ago. However, previously thought less common strains in the United States have gained in prevalence. The response to medications by non-B subtypes compared to B subtypes as well as whether the targeted mutations in non-B subtypes contribute to drug resistance the same as B subtypes need to be further studied. The purpose of this study was to identify whether HIV-1 viruses routinely tested using the ViroSeq assay in UTMB Molecular Diagnostics Laboratory are Group M Subtype B. HIV sequences generated between January and September of 2008 were aligned with HIV-1 subtype reference strains and analyzed by phylogenetic methods. About 16 of 588 HIV sequences (2.7%) examined were identified as non-B subtypes including 3 of 416 (0.7%) prisoner and 13 of 172 (7.6%) regular patient samples.
机译：基因型耐药性测试是HIV管理中的护理标准。 ViroSeq HIV-1基因分型系统通常用于检测可赋予特定类型的抗逆转录病毒药物抗性的HIV基因组突变，以帮助治疗HIV感染。值得注意的是，该试验已获得FDA批准，只能检测HIV-1 M组B型亚型病毒耐药性。当该测定法在大约十年前引入临床护理时，B型是发达县中最流行的菌株。但是，以前认为在美国不太常见的菌株已经盛行。与B亚型相比，非B亚型对药物的反应以及与B亚型相同的非B亚型的靶向突变是否有助于耐药性。这项研究的目的是确定在UTMB分子诊断实验室中使用ViroSeq分析常规检测的HIV-1病毒是否为M组B亚型。将2008年1月至2008年9月之间产生的HIV序列与HIV-1亚型参考菌株进行比对并进行分析通过系统发育方法。被检查的588个HIV序列中约有16个（2.7％）被确定为非B亚型，包括416名囚犯中的3名（0.7％）和172名正常患者样本中的13名（7.6％）。

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