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首页> 外文期刊>Journal of Molecular Biology Research >Biofilm of Pseudomonas aeruginosa in Nosocomial Infection
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Biofilm of Pseudomonas aeruginosa in Nosocomial Infection

机译：铜绿假单胞菌医院感染的生物膜

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摘要

Bacteria in natural, industrial and clinical settings predominantly live in biofilms, i.e., sessile structured microbial communities encased in self-produced extracellular matrix material. One of the most important characteristics of microbial biofilms is that the resident bacteria display a remarkable increased tolerance toward antimicrobial attack. Biofilms formed by opportunistic pathogenic bacteria are involved in devastating persistent medical device-associated infections, and chronic infections in individuals who are immune-compromised or otherwise impaired in the host defense. Because the use of conventional antimicrobial compounds in many cases cannot eradicate biofilms, there is an urgent need to develop alternative measures to combat biofilm infections. The present review is focussed on the important opportunistic pathogen and biofilm model organism Pseudomonas aeruginosa. Initially, biofilm infections where P. aeruginosa plays an important role are described. Subsequently, current insights into the molecular mechanisms involved in P.?aeruginosa biofilm formation and the associated antimicrobial tolerance are reviewed. And finally, based on our knowledge about molecular biofilm biology, a number of therapeutic strategies for combat of P.?aeruginosa biofilm infections are presented.
机译：在自然，工业和临床环境中的细菌主要生活在生物膜中，即在自生的细胞外基质材料中包裹的无柄结构微生物群落。微生物生物膜的最重要特征之一是，常驻细菌显示出显着提高的抗微生物攻击能力。由机会病原性细菌形成的生物膜参与破坏性持久性医疗设备相关的感染，以及免疫受损或宿主防御能力受损的个体的慢性感染。由于在许多情况下使用常规的抗菌化合物无法根除生物膜，因此迫切需要开发替代措施来对抗生物膜感染。目前的审查集中在重要的机会病原体和生物膜模型生物铜绿假单胞菌。最初，描述了铜绿假单胞菌起重要作用的生物膜感染。随后，审查了当前有关洞菌体育生物膜形成的分子机制和相关的抗菌素耐药性的见解。最后，根据我们对分子生物膜生物学的了解，提出了许多对抗绿脓杆菌生物膜感染的治疗策略。

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