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首页> 外文期刊>Journal of Molecular Biology Research >A Comparative Study on the Effect of Low-Dose Oral Ketamine and Subcutaneous Ketamine on Post General Anesthesia Delirium and Pain in Children Undergoing Inguinal Hernia Surgery
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A Comparative Study on the Effect of Low-Dose Oral Ketamine and Subcutaneous Ketamine on Post General Anesthesia Delirium and Pain in Children Undergoing Inguinal Hernia Surgery

机译：小剂量口服氯胺酮和皮下氯胺酮对腹股沟疝手术患儿全麻后Deli妄和疼痛影响的比较研究

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Objective: Acute pain is a common complication in children undergoing surgery. Acute pain and delirium are associated with agitated behavior, in which there is a risk that the patient causes harm to himself and others. Acute pain and delirium also dissatisfy parents and caregivers during recovery, prolong the recovery and hospitalization, and make more nursing care necessary. Material and Methods: In this study, 90 ASA I children, aged 3-8, and two candidates for elective inguinal hernia surgery were divided into three groups based on a random number table using block size of four. Parental permission was obtained beforehand. In group 1, 1mg/kg of ketamine (3cc) was administered orally. In group 2, 0.5mg/kg of ketamine was administered subcutaneously after the anesthetic induction. In Group 3, or control group, the same amount of normal saline was administered as the placebo, then the surgery got underway. Results: Comparing the administration of oral ketamine, subcutaneous ketamine and normal saline, the study showed that the pain was significantly higher in the placebo group at 30, 60, 90 and 120 minutes. Subcutaneous ketamine resulted in higher delirium at 30, 60, 90 and 120 minutes than the placebo and oral ketamine. Satisfaction of nurses from the patient's recovery was significantly higher in the oral ketamine group and subcutaneous ketamine group (p=0/007). The need for narcotics in the oral ketamine group and subcutaneous ketamine group was lower than the placebo group (p=0/001). Ketamine administration prolonged the length of stay in the PACU, but it did not increase the frequency of complications such as postoperative nausea and vomiting and laryngospasm or bronchospasm in the two groups during the recovery. Conclusion: In conclusion, the study indicated that oral administration of low-dose ketamine before surgery can reduce pain severity and spare the need for analgesics after surgery.
机译：目的：急性疼痛是接受手术治疗的儿童的常见并发症。急性疼痛和del妄与躁动不安相关，患者有可能对自己和他人造成伤害。急性疼痛和del妄也使康复期间的父母和护理人员不满意，延长了康复和住院时间，并需要进行更多的护理。资料和方法：在这项研究中，根据随机数表（每组4个），将90名3至8岁的ASA I儿童和两名进行选择性腹股沟疝的候选人分为三组。事先获得父母的许可。在第1组中，口服1mg / kg的氯胺酮（3cc）。在第2组中，麻醉诱导后皮下注射0.5mg / kg的氯胺酮。在第3组或对照组中，给予与安慰剂相同量的生理盐水，然后开始手术。结果：对比口服氯胺酮，皮下氯胺酮和生理盐水的给药，研究显示安慰剂组在30、60、90和120分钟时疼痛明显增加。与安慰剂和口服氯胺酮相比，皮下氯胺酮在30、60、90和120分钟时产生更高的del妄。口服氯胺酮组和皮下氯胺酮组的护士对患者恢复的满意度显着更高（p = 0/007）。口服氯胺酮组和皮下氯胺酮组对麻醉剂的需求低于安慰剂组（p = 0/001）。氯胺酮的给药延长了在PACU的住院时间，但并未增加两组在恢复过程中并发症的发生频率，如术后恶心和呕吐以及喉痉挛或支气管痉挛。结论：总之，该研究表明，术前口服小剂量氯胺酮可以减轻疼痛的严重程度，并且在术后无需镇痛药。

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