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首页> 外文期刊>Journal of Molecular Biochemistry >Alpha-linolenic acid regulates the growth of breast and cervical cancer cell lines through regulation of NO release and induction of lipid peroxidation
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Alpha-linolenic acid regulates the growth of breast and cervical cancer cell lines through regulation of NO release and induction of lipid peroxidation

机译：α-亚麻酸通过调节NO的释放和诱导脂质过氧化来调节乳腺癌和宫颈癌细胞的生长

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摘要

In the present work, we have analyzed the effect of the essential fatty acid, alpha linolenic acid (ALA) on nitric oxide release as well as induction of lipid peroxidation in breast (MCF-7 and MDA-MB-231) and cervical (SiHa and HeLa) cancer cell lines. ALA-treated cells showed a dose-dependent decrease in cell viability in both breast and cervical cancer cell lines without affecting the viability of non-cancerous transformed HEK 293 cells. Both types of cancer cells treated with ALA demonstrated a significant reduction in nitric oxide (NO) release with a simultaneous increase in lipid peroxidation (LPO). This was followed by a decrease in the mitochondrial membrane potential as well as activation of caspase 3 leading to apoptosis. Thus, ALA regulated the growth of cancer cell lines through induction of lipid peroxidation and modulation of nitric oxide release resulting in apoptosis.
机译：在目前的工作中，我们分析了必需脂肪酸，α亚麻酸（ALA）对一氧化氮释放以及诱导乳房（MCF-7和MDA-MB-231）和宫颈（SiHa）脂质过氧化的影响和HeLa）癌细胞系。经ALA处理的细胞在乳腺癌和宫颈癌细胞系中均显示出剂量依赖性的细胞生存力下降，而不会影响非癌性转化HEK 293细胞的生存能力。用ALA处理的两种类型的癌细胞均显示一氧化氮（NO）释放显着减少，而脂质过氧化（LPO）同时增加。其次是线粒体膜电位的降低以及胱天蛋白酶3的活化导致细胞凋亡。因此，ALA通过诱导脂质过氧化和调节一氧化氮释放导致细胞凋亡来调节癌细胞系的生长。

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