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首页> 外文期刊>Journal of neuroinflammation >Reduced serum concentrations of 25-hydroxy vitamin D in children with autism: Relation to autoimmunity
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Reduced serum concentrations of 25-hydroxy vitamin D in children with autism: Relation to autoimmunity

机译：自闭症儿童血清25-羟基维生素D浓度降低：与自身免疫的关系

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Background Aside from the skeletal health affection, vitamin D deficiency has been implicated as a potential environmental factor triggering for some autoimmune disorders. Vitamin D might play a role in the regulation of the production of auto-antibodies. Immunomodulatory effects of vitamin D may act not only through modulation of T-helper cell function, but also through induction of CD4+CD25high regulatory T-cells. We are the first to investigate the relationship between serum levels of 25-hydroxy vitamin D and anti-myelin-associated glycoprotein (anti-MAG) auto-antibodies in autistic children. Methods Serum levels of 25-hydroxy vitamin D and anti-MAG auto-antibodies were measured in 50 autistic children, aged between 5 and 12 years, and 30 healthy-matched children. Serum 25-hydroxy vitamin D levels 10–30 ng/mL and < 10 ng/mL were defined as vitamin D insufficiency and deficiency, respectively. Results Autistic children had significantly lower serum levels of 25-hydroxy vitamin D than healthy children (P < 0.001) with 40% and 48% being vitamin D deficient and insufficient, respectively. Serum 25-hydroxy vitamin D had significant negative correlations with Childhood Autism Rating Scale (P < 0.001). Increased levels of serum anti-MAG auto-antibodies were found in 70% of autistic patients. Serum 25-hydroxy vitamin D levels had significant negative correlations with serum levels of anti-MAG auto-antibodies (P < 0.001). Conclusions Vitamin D deficiency was found in some autistic children and this deficiency may contribute to the induction of the production of serum anti-MAG auto-antibodies in these children. However, future studies looking at a potential role of vitamin D in the pathophysiology and treatment of autism are warranted.
机译：背景技术除了对骨骼健康的影响外，维生素D缺乏症还被认为是引发某些自身免疫性疾病的潜在环境因素。维生素D可能在调节自身抗体的产生中起作用。维生素D的免疫调节作用不仅可以通过调节T辅助细胞功能发挥作用，还可以通过诱导CD4 + CD25high调节性T细胞发挥作用。我们是第一个研究自闭症儿童血清25-羟基维生素D水平与抗髓磷脂相关糖蛋白（anti-MAG）自身抗体之间的关系的人。方法对50名5至12岁的自闭症儿童和30名健康匹配的儿童进行血清25-羟基维生素D和抗MAG自身抗体的检测。血清25-羟基维生素D水平分别为10-30 ng / mL和<10 ng / mL，分别定义为维生素D功能不足和缺乏。结果自闭症儿童的25-羟基维生素D血清水平明显低于健康儿童（P <0.001），其中40％和48％的维生素D缺乏和不足。血清25-羟基维生素D与儿童自闭症评分量表具有显着负相关（P <0.001）。 70％的自闭症患者血清抗MAG自身抗体水平升高。血清25-羟基维生素D水平与抗MAG自身抗体的血清水平显着负相关（P <0.001）。结论在一些自闭症儿童中发现了维生素D缺乏症，这种缺乏症可能有助于诱导这些儿童的血清抗MAG自身抗体的产生。但是，有必要进行进一步研究，探讨维生素D在自闭症的病理生理和治疗中的潜在作用。

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