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首页> 外文期刊>Journal of Neuroscience and Behavioral Health >Effects of methamphetamine on the hippocampus of rats: Behavioural and morphological approach
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Effects of methamphetamine on the hippocampus of rats: Behavioural and morphological approach

机译：甲基苯丙胺对大鼠海马的影响：行为学和形态学方法

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This investigation examined the effects of methamphetamine (METH) on performance of rats using the Morris water maze and on the morphology of the hippocampus. Twelve adult Wistar rats were used for this study. Animals were randomly assigned into two groups (A and B) of six each. Group A rats served as control and were given normal saline. Group B animals were given single administration of METH (10 mg/kg, i.p.).? Animals were subjected to behavioural studies on the water maze prior to treatment. Three days following METH administration, animals were again subjected to behavioural studies, sacrificed, brain excised and processed histologically. Results showed high level of methamphetamine-induced stereotypic movement. There was no significant difference in behavioural performance of the rats on water maze prior to treatments, but group B rats showed significantly poor performance after treatment when compared to control (P<0.05). Histological analysis revealed extensive neuronal destruction of the pyramidal layer of the hippocampus following methamphetamine administration. In conclusion, this study has shown the neuro-destructive effects of METH on the hippocampus and such degenerating effects could affect the learning, memory and possibly spatial navigation ability of rats during the water maze task.
机译：这项研究调查了甲基苯丙胺（METH）对使用莫里斯水迷宫大鼠的行为以及海马形态的影响。十二只成年Wistar大鼠用于这项研究。将动物随机分为两组，每组六个。 A组大鼠作为对照组并给予生理盐水。给B组动物单次施用甲乙磺酸（10 mg / kg，腹腔注射）。在治疗之前，对动物进行水迷宫的行为研究。 METH给药三天后，再次对动物进行行为研究，处死，切除脑并进行组织学处理。结果表明，甲基苯丙胺引起的定型运动水平很高。治疗前大鼠在水迷宫上的行为表现无明显差异，但与对照组相比，B组大鼠治疗后表现显着差（P <0.05）。组织学分析显示，服用甲基苯丙胺后海马锥体层神经元受到广泛破坏。总之，这项研究表明了甲基苯丙氨酸甲酯对海马的神经破坏作用，这种退化作用可能会影响水迷宫任务期间大鼠的学习，记忆和可能的空间导航能力。

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