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首页> 外文期刊>Journal of Nutritional Science and Vitaminology >Coffee Improves Insulin-Stimulated Akt Phosphorylation in Liver and Skeletal Muscle in Diabetic KK- Ay Mice
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Coffee Improves Insulin-Stimulated Akt Phosphorylation in Liver and Skeletal Muscle in Diabetic KK- Ay Mice

机译：咖啡可改善胰岛素刺激的糖尿病KK-A y 小鼠肝脏和骨骼肌中的Akt磷酸化。

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Coffee has an anti-diabetic effect, specifically the amelioration of both hyperglycemia and insulin resistance, in KK- Ay mice, a type 2 diabetes animal model. To investigate coffee's effect on insulin signaling in liver, skeletal muscle, and adipose tissue (epididymal fat), we assayed the tyrosine phosphorylation of insulin receptor (IR) and serine phosphorylation of Akt. In Expt. 1, we assayed insulin signaling under nonfasting conditions in KK- Ay mice that ingested water or coffee for 4 wk. Coffee ingestion ameliorated the development of hyperglycemia but did not affect insulin signaling in liver or skeletal muscle under such conditions. In Expt. 2, we assayed insulin signaling under basal and insulin-stimulated conditions in KK- Ay mice that ingested water or coffee for 3 wk. The levels of tyrosine phosphorylation of insulin receptor in response to insulin injection in insulin-sensitive tissues were not different between mice that drank water and those that drank coffee. Coffee ingestion significantly increased the insulin-induced serine phosphorylation of Akt in liver and skeletal muscle, but not in epididymal fat, of KK- Ay mice. Our results also indicated that coffee ingestion may contribute to the improvement of insulin resistance and hyperglycemia in KK- Ay mice via the activation of Akt in insulin signaling in liver and skeletal muscle.
机译：咖啡在2型糖尿病动物模型KK-A y 小鼠中具有抗糖尿病作用，特别是高血糖和胰岛素抵抗的改善。为了调查咖啡对肝脏，骨骼肌和脂肪组织（附睾脂肪）中胰岛素信号传导的影响，我们分析了胰岛素受体（IR）的酪氨酸磷酸化和Akt的丝氨酸磷酸化。在Expt。如图1所示，我们在非禁食条件下测定了摄取水或咖啡4周的KK-A y 小鼠的胰岛素信号传导。在这种情况下，摄入咖啡可改善高血糖症的发生，但不影响肝脏或骨骼肌中的胰岛素信号传导。在Expt。如图2所示，我们在摄入水或咖啡3周的KK-A y 小鼠中，在基础和胰岛素刺激的条件下测定了胰岛素信号传导。在喝水的老鼠和喝咖啡的老鼠之间，胰岛素敏感性组织中响应于胰岛素注射的胰岛素受体的酪氨酸磷酸化水平没有差异。摄入咖啡可明显增加胰岛素诱导的KK-A y 小鼠肝脏和骨骼肌中Akt的丝氨酸磷酸化，但不影响附睾脂肪中的丝氨酸磷酸化。我们的结果还表明，摄入咖啡可能通过激活肝脏和骨骼肌胰岛素信号中的Akt来改善KK-A y 小鼠的胰岛素抵抗和高血糖症。

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