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首页> 外文期刊>Journal of Oral Microbiology >Xylitol and sorbitol effects on the microbiome of saliva and plaque
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Xylitol and sorbitol effects on the microbiome of saliva and plaque

机译：木糖醇和山梨糖醇对唾液和菌斑微生物组的影响

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ABSTRACT Chewing gum containing xylitol may help prevent caries by reducing levels of mutans streptococci (MS) and lactobacilli in saliva and plaque. Very little is known about other species which are possibly beneficial to oral health. In this study, we employed high-throughput sequencing of the 16S rRNA gene to profile microbial communities of saliva and plaque following short-term consumption of xylitol and sorbitol containing chewing gum. Participants ( n ?=?30) underwent a washout period and were randomly assigned to one of two groups. Each group chewed either xylitol or sorbitol gum for three weeks, before undergoing a second four-week washout period after which they switched to the alternate gum for three weeks. Analysis of samples collected before and after each intervention identified distinct plaque and saliva microbial communities that altered dependent on the order in which gum treatments were given. Neither the xylitol nor sorbitol treatments significantly affected the bacterial composition of plaque. Lactobacilli were undetected and the number of Streptococcus mutans sequence reads was very low and unaffected by either xylitol or sorbitol. However, sorbitol affected several other streptococcal species in saliva including increasing the abundance of S. cristatus , an oral commensal shown to inhibit bacteria associated with chronic periodontitis.
机译：摘要含有木糖醇的口香糖可通过减少唾液和菌斑中的变形链球菌（MS）和乳酸杆菌的含量来帮助预防龋齿。对于可能有益于口腔健康的其他物种知之甚少。在这项研究中，我们使用16S rRNA基因的高通量测序来分析短期食用含木糖醇和山梨糖醇的口香糖后唾液和菌斑的微生物群落。参与者（n≥30）经历了冲洗期，并被随机分配到两组中的一组。每组咀嚼木糖醇或山梨糖醇口香糖三周，然后经历第二个四周的冲洗期，之后他们换用备用口香糖三周。在每次干预之前和之后收集的样品的分析确定了不同的牙菌斑和唾液微生物群落，这些群落根据给予牙龈治疗的顺序而改变。木糖醇和山梨糖醇处理均未显着影响菌斑的细菌组成。未检测到乳杆菌，并且变形链球菌序列读取的数目非常低，并且不受木糖醇或山梨糖醇的影响。但是，山梨糖醇影响唾液中的其他几种链球菌，包括增加链球菌（S. cristatus）的丰度，这是一项口服药，可抑制与慢性牙周炎有关的细菌。

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