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首页> 外文期刊>Journal of pharmaceutical care. >Safe Handling of Cytotoxic Drugs and Risks of Occupational Exposure to Nursing Staffs
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Safe Handling of Cytotoxic Drugs and Risks of Occupational Exposure to Nursing Staffs

机译：细胞毒素药物的安全处理和护理人员职业接触的风险

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Background: Inherent toxicity of cytotoxic drugs is the basis for their potential adverse risks from occupational exposure to the nursing staff. In Iran, chemotherapy regimens are prescribed and administered according to the world updated protocols. But little is done regarding the protective standards in this field.Methods: An observational cross-sectional survey was conducted among nurses who work in three tertiary care teaching hospitals in Tehran, Iran in 2012. All participants worked in one of the hospital wards handling cytotoxic drugs (preparation and administration). A questionnaire was used for interviewing all subjects, and observing them preparing and administering the drugs. We examined all adverse effects associated with handling of antineoplastic drugs.Results: Totally 270 adverse reactions were reported. The most frequently reported adverse effects included headache and vertigo (40 cases), hair loss (36 cases), skin rashes and itching (31 cases), and burning sensation in eyes (31 cases). In all hospital wards, the standards were met in not more than 50% of the items.Conclusion: Monitoring the personnel who are directly involved in handling of cytotoxic drugs is of great importance. Furthermore, educating the personnel in the field of standards of cytotoxic drugs handling could increase the nursing staff’s knowledge regarding these drugs’ adverse reactions.
机译：背景：细胞毒性药物的固有毒性是其因职业性接触护理人员而可能产生潜在不良风险的基础。在伊朗，根据世界最新协议规定并管理化疗方案。方法：对2012年在伊朗德黑兰三所三级教学医院工作的护士进行了观察性横断面调查。所有参与者均在其中一家处理细胞毒性的病房工作药物（制备和给药）。问卷用于采访所有受试者，并观察他们的准备和使用药物。我们检查了与抗肿瘤药治疗相关的所有不良反应。结果：共报告了270种不良反应。最常见的不良反应包括头痛和眩晕（40例），脱发（36例），皮疹和瘙痒（31例）和眼睛灼热感（31例）。在所有医院病房中，不超过50％的项目都达到了标准。结论：对直接参与细胞毒药物处理的人员进行监控非常重要。此外，对细胞毒性药物处理标准领域的人员进行教育可能会增加护理人员对这些药物不良反应的了解。

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